8GEO
E. eligens beta-glucuronidase bound to 3-OH-desloratidine-glucuronide
Summary for 8GEO
Entry DOI | 10.2210/pdb8geo/pdb |
Descriptor | Beta-glucuronidase, 8-chloro-11-(1-beta-D-glucopyranuronosylpiperidin-4-ylidene)-3-hydroxy-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine, GLYCEROL, ... (4 entities in total) |
Functional Keywords | beta-glucuronidase, inhibitor, glucuronide, hydrolase |
Biological source | Lachnospira eligens |
Total number of polymer chains | 1 |
Total formula weight | 70522.25 |
Authors | Simpson, J.B.,Redinbo, M.R. (deposition date: 2023-03-07, release date: 2024-03-20, Last modification date: 2024-06-26) |
Primary citation | Simpson, J.B.,Walker, M.E.,Sekela, J.J.,Ivey, S.M.,Jariwala, P.B.,Storch, C.M.,Kowalewski, M.E.,Graboski, A.L.,Lietzan, A.D.,Walton, W.G.,Davis, K.A.,Cloer, E.W.,Borlandelli, V.,Hsiao, Y.C.,Roberts, L.R.,Perlman, D.H.,Liang, X.,Overkleeft, H.S.,Bhatt, A.P.,Lu, K.,Redinbo, M.R. Gut microbial beta-glucuronidases influence endobiotic homeostasis and are modulated by diverse therapeutics. Cell Host Microbe, 32:925-944.e10, 2024 Cited by PubMed: 38754417DOI: 10.1016/j.chom.2024.04.018 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.89 Å) |
Structure validation
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