6P2B

Tethered PXR-LBD/SRC-1p bound to Garcinoic Acid

Summary for 6P2B

Entry DOI	10.2210/pdb6p2b/pdb
Descriptor	Nuclear receptor subfamily 1 group I member 2, (2Z,6E,10E)-13-[(2R)-6-hydroxy-2,8-dimethyl-3,4-dihydro-2H-1-benzopyran-2-yl]-2,6,10-trimethyltrideca-2,6,10-trienoic acid, DIMETHYL SULFOXIDE, ... (4 entities in total)
Functional Keywords	garcinoic acid, nuclear receptor, transcription
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	79455.65
Authors	Walton, W.G.,Pellock, S.J.,Redinbo, M.R. (deposition date: 2019-05-21, release date: 2020-04-01, Last modification date: 2023-10-11)
Primary citation	Bartolini, D.,De Franco, F.,Torquato, P.,Marinelli, R.,Cerra, B.,Ronchetti, R.,Schon, A.,Fallarino, F.,De Luca, A.,Bellezza, G.,Ferri, I.,Sidoni, A.,Walton, W.G.,Pellock, S.J.,Redinbo, M.R.,Mani, S.,Pellicciari, R.,Gioiello, A.,Galli, F. Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. J.Med.Chem., 63:3701-3712, 2020 Cited by PubMed: 32160459 DOI: 10.1021/acs.jmedchem.0c00012 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation