8SL7

Butyricicoccus sp. BIOML-A1 tryptophanase complex with (3S) ALG-05

Summary for 8SL7

Entry DOI	10.2210/pdb8sl7/pdb
Descriptor	Tryptophanase, (E)-3-[(3S)-3-chloro-2-oxo-2,3-dihydro-1H-indol-3-yl]-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-alanine (3 entities in total)
Functional Keywords	tryptophan-indole lyase, tryptophananse, plp-dependent enzyme, inhibitor-bound complex, lyase
Biological source	Butyricicoccus sp. BIOML-A1
Total number of polymer chains	4
Total formula weight	260638.62
Authors	Graboski, A.L.,Redinbo, M.R. (deposition date: 2023-04-21, release date: 2023-08-23, Last modification date: 2023-11-29)
Primary citation	Graboski, A.L.,Kowalewski, M.E.,Simpson, J.B.,Cao, X.,Ha, M.,Zhang, J.,Walton, W.G.,Flaherty, D.P.,Redinbo, M.R. Mechanism-based inhibition of gut microbial tryptophanases reduces serum indoxyl sulfate. Cell Chem Biol, 30:1402-1413.e7, 2023 Cited by PubMed: 37633277 DOI: 10.1016/j.chembiol.2023.07.015 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.07 Å)

Structure validation