8UGT

E. eligens beta-glucuronidase bound to UNC10206581-G

Summary for 8UGT

• Entry DOI: 10.2210/pdb8ugt/pdb
• Descriptor: Beta-glucuronidase, 8-(4-beta-D-glucopyranuronosylpiperazin-1-yl)-5-(methylamino)-1,2,3,4-tetrahydro[1,2,3]triazino[4',5':4,5]thieno[2,3-c]isoquinoline, N-methyl-8-(piperazin-1-yl)-1,2,3,4-tetrahydro[1,2,3]triazino[4',5':4,5]thieno[2,3-c]isoquinolin-5-amine, ... (4 entities in total)
• Functional Keywords: beta-glucuronidase, inhibitor, glucuronide, hydrolase
• Biological source: Lachnospira eligens
• Total number of polymer chains: 1
• Total formula weight: 70906.35

Authors

Simpson, J.B.,Redinbo, M.R. (deposition date: 2023-10-06, release date: 2024-07-24)

• Primary citation: Graboski, A.L.,Simpson, J.B.,Pellock, S.J.,Mehta, N.,Creekmore, B.C.,Ariyarathna, Y.,Bhatt, A.P.,Jariwala, P.B.,Sekela, J.J.,Kowalewski, M.E.,Barker, N.K.,Mordant, A.L.,Borlandelli, V.B.,Overkleeft, H.,Herring, L.E.,Jin, J.,I.James, L.,Redinbo, M.R.; Advanced piperazine-containing inhibitors target microbial beta-glucuronidases linked to gut toxicity; Rsc Chem Biol, 2024; DOI: 10.1039/D4CB00058G

Experimental method

X-RAY DIFFRACTION (2.65 Å)