8UMG

Chromodomains of human CHD1 complexed with UNC10142

Summary for 8UMG

• Entry DOI: 10.2210/pdb8umg/pdb
• Descriptor: Chromodomain-helicase-DNA-binding protein 1, 1-{4-[{2-(azonan-1-yl)-6-methoxy-7-[3-(piperidin-1-yl)propoxy]quinazolin-4-yl}(methyl)amino]piperidin-1-yl}ethan-1-one, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: chd1, chromodomain-helicase dna-binding 1, methyllysine reader, peptide binding protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 3
• Total formula weight: 67672.80

Authors

Graboski, A.L.,Redinbo, M.R. (deposition date: 2023-10-17, release date: 2024-10-23)

• Primary citation: Johnson, R.L.,Graboski, A.L.,Walton, W.G.,James, L.I.,Redinbo, M.R.; Optimization of a quinazoline-based scaffold against human CHD1; To Be Published,

Experimental method

X-RAY DIFFRACTION (3.1 Å)