8UMG

Chromodomains of human CHD1 complexed with UNC10142

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	Chromodomain-helicase-DNA-binding protein 1	polymer	187	22146.8	3	UniProt (O14646) Pfam (PF00385)	Homo sapiens (human)	CHD-1,ATP-dependent helicase CHD1
2	D, E (A, B)	1-{4-[{2-(azonan-1-yl)-6-methoxy-7-[3-(piperidin-1-yl)propoxy]quinazolin-4-yl}(methyl)amino]piperidin-1-yl}ethan-1-one	non-polymer		580.8	2	Chemie (X31)
3	F, G (B)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
4	H, I, J (A, B, C)	water	water		18.0	99	Chemie (HOH)

Sequence modifications

A, B, C: 10 - 187 (UniProt: O14646)

PDB	External Database	Details
Met 1	-	expression tag
Lys 2	-	expression tag
Lys 3	-	expression tag
His 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
His 9	-	expression tag
Gly 134	Glu 392	conflict
Lys 186	Asn 444	engineered mutation
Lys 187	Gln 445	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	66440.3
Non-Polymers*	Number of molecules	4
	Total formula weight	1232.5
All*	Total formula weight	67672.8

*Water molecules are not included.