1A31

HUMAN RECONSTITUTED DNA TOPOISOMERASE I IN COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX

Summary for 1A31

DescriptorDNA (5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*5IUP*5IU*TP*GP*AP*AP*AP*AP*AP*5IUP*5IUP*5IUP*5IUP*T)-3'), DNA (5'-D(*AP*AP*AP*AP*AP*TP*5IUP*5IUP*5IUP*5IUP*CP*AP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3'), PROTEIN (TOPOISOMERASE I), ... (4 entities in total)
Functional Keywordstopoisomerase i/dna, dna, topoisomerase i, isomerase-dna complex, isomerase/dna
Biological sourceHomo sapiens (human)
Cellular locationNucleus, nucleolus  
Total number of polymer chains3
Total molecular weight84733.39
Authors
Redinbo, M.R.,Stewart, L.,Kuhn, P.,Champoux, J.J.,Hol, W.G.J. (deposition date: 1998-01-27, release date: 1998-08-28, Last modification date: 2011-07-13)
Primary citation
Redinbo, M.R.,Stewart, L.,Kuhn, P.,Champoux, J.J.,Hol, W.G.
Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA.
Science, 279:1504-1513, 1998
PubMed: 9488644 (PDB entries with the same primary citation)
DOI: 10.1126/science.279.5356.1504
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.1 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers220.9%3.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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