1A31
HUMAN RECONSTITUTED DNA TOPOISOMERASE I IN COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX
Summary for 1A31
Entry DOI | 10.2210/pdb1a31/pdb |
Descriptor | DNA (5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*5IUP*5IU*TP*GP*AP*AP*AP*AP*AP*5IUP*5IUP*5IUP*5IUP*T)-3'), DNA (5'-D(*AP*AP*AP*AP*AP*TP*5IUP*5IUP*5IUP*5IUP*CP*AP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3'), PROTEIN (TOPOISOMERASE I), ... (4 entities in total) |
Functional Keywords | topoisomerase i/dna, dna, topoisomerase i, isomerase-dna complex, isomerase/dna |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus, nucleolus : |
Total number of polymer chains | 3 |
Total formula weight | 84733.38 |
Authors | Redinbo, M.R.,Stewart, L.,Kuhn, P.,Champoux, J.J.,Hol, W.G.J. (deposition date: 1998-01-27, release date: 1998-08-28, Last modification date: 2011-07-13) |
Primary citation | Redinbo, M.R.,Stewart, L.,Kuhn, P.,Champoux, J.J.,Hol, W.G. Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA. Science, 279:1504-1513, 1998 Cited by PubMed: 9488644DOI: 10.1126/science.279.5356.1504 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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