Author results

2Y6W
  • Download 2y6w
  • View 2y6w
Molmil generated image of 2y6w
STRUCTURE OF A BCL-W DIMER
Descriptor:BCL-2-LIKE PROTEIN 2, DI(HYDROXYETHYL)ETHER, TRIETHYLENE GLYCOL
Authors:Lee, E.F., Evangelista, M., Pettikiriarachchi, A., Dogovski, C., Perugini, M.A., Colman, P.M., Fairlie, W.D.
Deposit date:2011-01-27
Release date:2011-10-26
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of a Bcl-W Domain-Swapped Dimer: Implications for the Function of Bcl-2 Family Proteins.
Structure, 19, 2011
2YJ1
  • Download 2yj1
  • View 2yj1
Molmil generated image of 2yj1
PUMA BH3 FOLDAMER IN COMPLEX WITH BCL-XL
Descriptor:BCL-2-LIKE PROTEIN 1, ALPHA-BETA-PUMA BH3 FOLDAMER
Authors:Lee, E.F., Smith, B.J., Horne, W.S., Mayer, K.N., Evangelista, M., Colman, P.M., Gellman, S.H., Fairlie, W.D.
Deposit date:2011-05-18
Release date:2011-10-12
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Structural Basis of Bcl-Xl Recognition by a Bh3-Mimetic Alpha-Beta-Peptide Generated Via Sequence-Based Design
Chembiochem, 12, 2011
3D7V
  • Download 3d7v
  • View 3d7v
Molmil generated image of 3d7v
CRYSTAL STRUCTURE OF MCL-1 IN COMPLEX WITH AN MCL-1 SELECTIVE BH3 LIGAND
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1, Bcl-2-like protein 11, ZINC ION
Authors:Lee, E.F., Czabotar, P.E., Colman, P.M., Fairlie, W.D.
Deposit date:2008-05-22
Release date:2008-06-24
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation.
J.Cell Biol., 180, 2008
3QBR
  • Download 3qbr
  • View 3qbr
Molmil generated image of 3qbr
BAKBH3 IN COMPLEX WITH SJA
Descriptor:SJCHGC06286 protein, Bcl-2 homologous antagonist/killer, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID
Authors:Lee, E.F., Clarke, O.B., Fairlie, W.D., Colman, P.M., Evangelista, M., Feng, Z., Speed, T.P., Tchoubrieva, E., Strasser, A., Kalinna, B.
Deposit date:2011-01-13
Release date:2011-04-13
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:Discovery and molecular characterization of a Bcl-2-regulated cell death pathway in schistosomes.
Proc.Natl.Acad.Sci.USA, 108, 2011
5VAU
  • Download 5vau
  • View 5vau
Molmil generated image of 5vau
BCL-2 COMPLEX WITH BECLIN 1 BH3 DOMAIN
Descriptor:Apoptosis regulator Bcl-2 -- Bcl-2-like protein 1 Chimera, Beclin-1
Authors:Lee, E.F., Smith, B.J., Yao, S., Fairlie, W.D.
Deposit date:2017-03-28
Release date:2018-04-04
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.754 Å)
Cite:Bcl-2 complex with Beclin 1 BH3 domain
To Be Published
5VAX
  • Download 5vax
  • View 5vax
Molmil generated image of 5vax
BCL-2 COMPLEX WITH BECLIN 1 BH3 DOMAIN
Descriptor:Apoptosis regulator Bcl-2 -- Bcl-2-like protein 1 Chimera, Beclin-1
Authors:Lee, E.F., Smith, B.J., Yao, S., Fairlie, W.D.
Deposit date:2017-03-28
Release date:2018-04-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Bcl-2 complex with Beclin 1 pT108 BH3 domain
To Be Published
5VAY
  • Download 5vay
  • View 5vay
Molmil generated image of 5vay
BCL-2 COMPLEX WITH BECLIN 1 T108D BH3 DOMAIN
Descriptor:Apoptosis regulator Bcl-2 -- Bcl-2-like protein 1 Chimera, Beclin-1
Authors:Lee, E.F., Smith, B.J., Yao, S., Fairlie, W.D.
Deposit date:2017-03-28
Release date:2018-04-04
Method:X-RAY DIFFRACTION (1.804 Å)
Cite:Bcl-2 complex with Beclin 1 pT108 BH3 domain
To Be Published
6DCN
  • Download 6dcn
  • View 6dcn
Molmil generated image of 6dcn
BCL-XL COMPLEX WITH BECLIN 1 BH3 DOMAIN T108PTHR
Descriptor:BCL-xl protein, Beclin-1
Authors:Lee, E.F., Smith, B.J., Smith, N.A., Yao, S., Fairlie, W.D.
Deposit date:2018-05-07
Release date:2018-05-23
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (2.444 Å)
Cite:Structural insights into BCL2 pro-survival protein interactions with the key autophagy regulator BECN1 following phosphorylation by STK4/MST1.
Autophagy, 15, 2019
6DCO
  • Download 6dco
  • View 6dco
Molmil generated image of 6dco
BCL-XL COMPLEX WITH BECLIN 1 BH3 DOMAIN T108D
Descriptor:Bcl-2-like protein 1,Bcl-2-like protein 1, Beclin-1, CHLORIDE ION
Authors:Lee, E.F., Smith, B.J., Smith, N.A., Yao, S., Fairlie, W.D.
Deposit date:2018-05-07
Release date:2018-05-30
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (2.198 Å)
Cite:Structural insights into BCL2 pro-survival protein interactions with the key autophagy regulator BECN1 following phosphorylation by STK4/MST1.
Autophagy, 15, 2019
2YXJ
  • Download 2yxj
  • View 2yxj
Molmil generated image of 2yxj
CRYSTAL STRUCTURE OF BCL-XL IN COMPLEX WITH ABT-737
Descriptor:Apoptosis regulator Bcl-X, CHLORIDE ION, 4-{4-[(4'-CHLOROBIPHENYL-2-YL)METHYL]PIPERAZIN-1-YL}-N-{[4-({(1R)-3-(DIMETHYLAMINO)-1-[(PHENYLTHIO)METHYL]PROPYL}AMINO)-3-NITROPHENYL]SULFONYL}BENZAMIDE, ...
Authors:Czabotar, P.E., Lee, E.F., Smith, B.J., Deshayes, K., Zobel, K., Fairlie, W.D., Colman, P.M.
Deposit date:2007-04-26
Release date:2007-05-22
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family
Cell Death Differ., 14, 2007
3FDL
  • Download 3fdl
  • View 3fdl
Molmil generated image of 3fdl
BIM BH3 PEPTIDE IN COMPLEX WITH BCL-XL
Descriptor:Apoptosis regulator Bcl-X, Bcl-2-like protein 11
Authors:Fairlie, W.D., Lee, E.F., Smith, B.J., Czabotar, P.E., Colman, P.M.
Deposit date:2008-11-26
Release date:2009-03-10
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:High-Resolution Structural Characterization of a Helical alpha/beta-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-x(L)
Angew.Chem.Int.Ed.Engl., 48, 2009
3FDM
  • Download 3fdm
  • View 3fdm
Molmil generated image of 3fdm
ALPHA/BETA FOLDAMER IN COMPLEX WITH BCL-XL
Descriptor:Apoptosis regulator Bcl-X, alpha/beta-peptide foldamer, 1,2-ETHANEDIOL
Authors:Fairlie, W.D., Lee, E.F., Smith, B.J., Czabotar, P.E., Colman, P.M., Sadowsky, J.D., Peterson-Kaufman, K.J., Gellman, S.H.
Deposit date:2008-11-26
Release date:2009-03-10
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:High-Resolution Structural Characterization of a Helical alpha/beta-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-x(L)
Angew.Chem.Int.Ed.Engl., 48, 2009
3INQ
  • Download 3inq
  • View 3inq
Molmil generated image of 3inq
CRYSTAL STRUCTURE OF BCL-XL IN COMPLEX WITH W1191542
Descriptor:Bcl-2-like protein 1, 4-[4-(biphenyl-3-ylmethyl)piperazin-1-yl]-N-{[4-({(1R)-3-(dimethylamino)-1-[(phenylsulfanyl)methyl]propyl}amino)-3-nitrophenyl]sulfonyl}benzamide, 1,2-ETHANEDIOL, ...
Authors:Fairlie, W.D., Smith, B.J., Colman, P.M., Czabotar, P.E., Lee, E.F.
Deposit date:2009-08-12
Release date:2009-09-01
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands
J. Biol. Chem., 284, 2009
3IO8
  • Download 3io8
  • View 3io8
Molmil generated image of 3io8
BIML12F IN COMPLEX WITH BCL-XL
Descriptor:Bcl-2-like protein 1, Bcl-2-like protein 11, ZINC ION
Authors:Colman, P.M., Lee, E.F., Fairlie, W.D., Smith, B.J., Czabotar, P.E., Yang, H., Sleebs, B.E., Lessene, G.
Deposit date:2009-08-14
Release date:2009-09-01
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands.
J.Biol.Chem., 284, 2009
3IO9
  • Download 3io9
  • View 3io9
Molmil generated image of 3io9
BIML12Y IN COMPLEX WITH MCL-1
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1, Bcl-2-like protein 11, ZINC ION
Authors:Czabotar, P.E., Lee, E.F., Yang, H., Sleebs, B.E., Lessene, G., Colman, P.M., Smith, B.J., Fairlie, W.D.
Deposit date:2009-08-14
Release date:2009-09-01
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands.
J.Biol.Chem., 284, 2009
4CIM
  • Download 4cim
  • View 4cim
Molmil generated image of 4cim
COMPLEX OF A BCL-W BH3 MUTANT WITH A BH3 DOMAIN
Descriptor:BCL-2-LIKE PROTEIN 2, 1,2-ETHANEDIOL
Authors:Colman, P.M., Lee, E.F., Fairlie, W.D.
Deposit date:2013-12-12
Release date:2014-11-12
Last modified:2015-01-14
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The Functional Differences of Pro-Survival and Pro-Apoptotic B Cell Lymphoma 2 (Bcl-2) Proteins Depend on Structural Differences in Their Bcl-2 Homology 3 (Bh3) Domains
J.Biol.Chem., 289, 2014
4CIN
  • Download 4cin
  • View 4cin
Molmil generated image of 4cin
COMPLEX OF BCL-XL WITH ITS BH3 DOMAIN
Descriptor:BCL-2-LIKE PROTEIN 1, CALCIUM ION, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Colman, P.M., Lee, E.F., Fairlie, W.D.
Deposit date:2013-12-12
Release date:2014-11-12
Last modified:2015-01-14
Method:X-RAY DIFFRACTION (2.693 Å)
Cite:The Functional Differences of Pro-Survival and Pro-Apoptotic B Cell Lymphoma 2 (Bcl-2) Proteins Depend on Structural Differences in Their Bcl-2 Homology 3 (Bh3) Domains
J.Biol.Chem., 289, 2014
5FMI
  • Download 5fmi
  • View 5fmi
Molmil generated image of 5fmi
HUMAN BAK Q77L
Descriptor:BCL-2 HOMOLOGOUS ANTAGONIST/KILLER, ZINC ION
Authors:Fairlie, W.D., Lee, E.F., Smith, B.J.
Deposit date:2015-11-06
Release date:2016-06-01
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (1.491 Å)
Cite:Physiological Restraint of Bak by Bcl-Xl is Essential for Cell Survival.
Genes Dev., 30, 2016
5FMJ
  • Download 5fmj
  • View 5fmj
Molmil generated image of 5fmj
BCL-XL WITH MOUSE BAK BH3 Q75L COMPLEX
Descriptor:BCL-2-LIKE PROTEIN 1, BAK1 PROTEIN, 1,2-ETHANEDIOL
Authors:Fairlie, W.D., Lee, E.F., Smith, B.J.
Deposit date:2015-11-06
Release date:2016-06-01
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Physiological Restraint of Bak by Bcl-Xl is Essential for Cell Survival.
Genes Dev., 30, 2016
5FMK
  • Download 5fmk
  • View 5fmk
Molmil generated image of 5fmk
BCL-XL WITH BAK BH3 COMPLEX
Descriptor:BCL-XL, BCL-2 HOMOLOGOUS ANTAGONIST/KILLER, GLYCEROL
Authors:Fairlie, W.D., Lee, E.F., Smith, B.J., Czabotar, P.E., Colman, P.M.
Deposit date:2015-11-06
Release date:2016-06-01
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.731 Å)
Cite:Physiological Restraint of Bak by Bcl-Xl is Essential for Cell Survival.
Genes Dev., 30, 2016
1Q2J
  • Download 1q2j
  • View 1q2j
Molmil generated image of 1q2j
STRUCTURAL BASIS FOR TETRODOTOXIN-RESISTANT SODIUM CHANNEL BINDING BY MU-CONOTOXIN SMIIIA
Descriptor:mu-conotoxin SmIIIA
Authors:Keizer, D.W., West, P.J., Lee, E.F., Olivera, B.M., Bulaj, G., Yoshikami, D., Norton, R.S.
Deposit date:2003-07-24
Release date:2004-02-24
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural basis for tetrodotoxin-resistant sodium channel binding by mu-conotoxin SmIIIA.
J.Biol.Chem., 278, 2003
2JBX
  • Download 2jbx
  • View 2jbx
Molmil generated image of 2jbx
CRYSTAL STRUCTURE OF THE MYXOMA VIRUS ANTI-APOPTOTIC PROTEIN M11L
Descriptor:M11L PROTEIN
Authors:Kvansakul, M., Van Delft, M.F., Lee, E.F., Gulbis, J.M., Fairlie, W.D., Huang, D.C.S., Colman, P.M.
Deposit date:2006-12-14
Release date:2007-03-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:A Structural Viral Mimic of Prosurvival Bcl-2: A Pivotal Role for Sequestering Proapoptotic Bax and Bak.
Mol.Cell, 25, 2007
2JBY
  • Download 2jby
  • View 2jby
Molmil generated image of 2jby
A VIRAL PROTEIN UNEXPECTEDLY MIMICS THE STRUCTURE AND FUNCTION OF PRO- SURVIVAL BCL-2
Descriptor:M11L PROTEIN, BCL-2 HOMOLOGOUS ANTAGONIST/KILLER 2, SODIUM ION
Authors:Kvansakul, M., Van Delft, M.F., Lee, E.F., Gulbis, J.M., Fairlie, W.D., Huang, D.C.S., Colman, P.M.
Deposit date:2006-12-14
Release date:2007-03-27
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak.
Mol. Cell, 25, 2007
2JM6
  • Download 2jm6
  • View 2jm6
Molmil generated image of 2jm6
SOLUTION STRUCTURE OF MCL-1 COMPLEXED WITH NOXAB
Descriptor:Noxa, Myeloid cell leukemia-1 protein Mcl-1 homolog
Authors:Czabotar, P.E., Lee, E.F., van Delft, M.F., Day, C.L., Smith, B.J., Huang, D.C.S., Fairlie, W.D., Hinds, M.G., Colman, P.M.
Deposit date:2006-10-17
Release date:2007-03-20
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural insights into the degradation of Mcl-1 induced by BH3 domains
Proc.Natl.Acad.Sci.Usa, 104, 2007
2ROC
  • Download 2roc
  • View 2roc
Molmil generated image of 2roc
SOLUTION STRUCTURE OF MCL-1 COMPLEXED WITH PUMA
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1 homolog, Bcl-2-binding component 3
Authors:Day, C.L., Smits, C., Fan, F.C., Lee, E.F., Fairlie, W.D., Hinds, M.G.
Deposit date:2008-03-17
Release date:2008-07-08
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of the BH3 Domains from the p53-Inducible BH3-Only Proteins Noxa and Puma in Complex with Mcl-1
J.Mol.Biol., 380, 2008
<123>