Author results

3JSD
  • Download 3jsd
  • View 3jsd
Molmil generated image of 3jsd
INSULIN'S BIOSYNTHESIS AND ACTIVITY HAVE OPPOSING STRUCTURAL REQUIREMENTS: A NEW FACTOR IN NEONATAL DIABETES MELLITUS
Descriptor:Insulin A chain, Insulin B chain, ZINC ION, ...
Authors:Weiss, M.A., Wan, Z.L., Dodson, E.J., Liu, M., Xu, B., Hua, Q.X., Turkenburg, M., Whittingham, J., Nakagawa, S.H., Huang, K., Hu, S.Q., Jia, W.H., Wang, S.H., Brange, J., Whittaker, J., Arvan, P., Katsoyannis, P.G., Dodson, G.G.
Deposit date:2009-09-10
Release date:2010-09-15
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
To be Published
3P2X
  • Download 3p2x
  • View 3p2x
Molmil generated image of 3p2x
INSULIN FIBRILLATION IS THE JANUS FACE OF INDUCED FIT. A CHIARAL CLAMP STABILIZES THE NATIVE STATE AT THE EXPENSE OF ACTIVITY
Descriptor:Insulin, ZINC ION, CHLORIDE ION, ...
Authors:Hua, Q.X., Wan, Z.L., Huang, K., Hu, S.Q., Phillip, N.F., Jia, W.H., Whittingham, J., Dodson, G.G., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2010-10-04
Release date:2011-11-23
Last modified:2014-10-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity
To be Published
3P33
  • Download 3p33
  • View 3p33
Molmil generated image of 3p33
INSULIN FIBRILLATION IS THE JANUS FACE OF INDUCED FIT. A CHIRAL CLAMP STABILIZES THE NATIVE STATE AT THE EXPENSE OF ACTIVITY
Descriptor:Insulin, PHENOL, ZINC ION, ...
Authors:Hua, Q.X., Wan, Z.L., Huang, K., Hu, S.Q., Phillip, N.F., Jia, W.H., Whittingham, J., Dodson, G.G., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2010-10-04
Release date:2011-11-23
Last modified:2014-10-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity
To be Published
3ROV
  • Download 3rov
  • View 3rov
Molmil generated image of 3rov
INSULIN'S BIOSYNTHESIS AND ACTIVITY HAVE OPPOSING STRUCTURAL REQUIREMENTS: A NEW FACTOR IN NEONATAL DIABETES MELLITUS
Descriptor:Insulin, PHENOL, ZINC ION, ...
Authors:Weiss, M.A., Wan, Z.L., Dodson, E.J., Liu, M., Xu, B., Hua, Q.X., Turkenburg, M., Whittingham, J., Nakagawa, S.H., Huang, K., Hu, S.Q., Jia, W.H., Wang, S.H., Brange, J., Whittaker, J., Arvan, P., Katsoyannis, P.G., Dodson, G.G.
Deposit date:2011-04-26
Release date:2012-05-02
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
To be Published
1J73
  • Download 1j73
  • View 1j73
Molmil generated image of 1j73
CRYSTAL STRUCTURE OF AN UNSTABLE INSULIN ANALOG WITH NATIVE ACTIVITY.
Descriptor:insulin a, insulin b, ZINC ION
Authors:Wan, Z., Zhao, M., Nakagawa, S., Jia, W., Weiss, M.A.
Deposit date:2001-05-15
Release date:2001-05-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Non-standard insulin design: structure-activity relationships at the periphery of the insulin receptor.
J.Mol.Biol., 315, 2002
1SJT
  • Download 1sjt
  • View 1sjt
Molmil generated image of 1sjt
MINI-PROINSULIN, TWO CHAIN INSULIN ANALOG MUTANT: DES B30, HIS(B 10)ASP, PRO(B 28)ASP, NMR, 20 STRUCTURES
Descriptor:PROINSULIN
Authors:Hua, Q.X., Hu, S.Q., Jia, W.H., Chu, Y.C., Burke, G.T., Wang, S.H., Katsoyannis, P.G., Weiss, M.A.
Deposit date:1997-10-09
Release date:1998-03-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Mini-proinsulin and mini-IGF-I: homologous protein sequences encoding non-homologous structures.
J.Mol.Biol., 277, 1998
1SJU
  • Download 1sju
  • View 1sju
Molmil generated image of 1sju
MINI-PROINSULIN, SINGLE CHAIN INSULIN ANALOG MUTANT: DES B30, HIS(B 10)ASP, PRO(B 28)ASP AND PEPTIDE BOND BETWEEN LYS B 29 AND GLY A 1, NMR, 20 STRUCTURES
Descriptor:PROINSULIN
Authors:Hua, Q.X., Hu, S.Q., Jia, W.H., Chu, Y.C., Burke, G.T., Wang, S.H., Katsoyannis, P.G., Weiss, M.A.
Deposit date:1997-10-09
Release date:1998-03-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Mini-proinsulin and mini-IGF-I: homologous protein sequences encoding non-homologous structures.
J.Mol.Biol., 277, 1998
1VKT
  • Download 1vkt
  • View 1vkt
Molmil generated image of 1vkt
HUMAN INSULIN TWO DISULFIDE MODEL, NMR, 10 STRUCTURES
Descriptor:INSULIN
Authors:Hua, Q.X., Hu, S.Q., Frank, B.H., Jia, W.H., Chu, Y.C., Wang, S.H., Burke, G.T., Katsoyannis, P.G., Weiss, M.A.
Deposit date:1996-10-14
Release date:1997-04-01
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Mapping the functional surface of insulin by design: structure and function of a novel A-chain analogue.
J.Mol.Biol., 264, 1996
2JMN
  • Download 2jmn
  • View 2jmn
Molmil generated image of 2jmn
NMR STRUCTURE OF HUMAN INSULIN MUTANT HIS-B10-ASP, PRO-B28-LYS, LYS-B29-PRO, 20 STRUCTURES
Descriptor:Insulin A chain, Insulin B chain
Authors:Hua, Q.X., Hu, S.Q., Frank, B.H., Jia, W.H., Chu, Y.C., Wang, S.H., Burke, G.T., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2006-11-21
Release date:2006-12-05
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Mapping the functional surface of insulin by design: structure and function of a novel A-chain analogue.
J.Mol.Biol., 264, 1996
2JZQ
  • Download 2jzq
  • View 2jzq
Molmil generated image of 2jzq
DESIGN OF AN ACTIVE ULTRA-STABLE SINGLE-CHAIN INSULIN ANALOG 20 STRUCTURES
Descriptor:Insulin
Authors:Hua, Q.X., Nakarawa, S., Jia, W.H., Huang, K., Philips, N.F., Hu, S.Q., Weiss, M.A.
Deposit date:2008-01-11
Release date:2008-02-26
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Design of an active ultrastable single-chain insulin analog: synthesis, structure, and therapeutic implications.
J.Biol.Chem., 283, 2008
2K91
  • Download 2k91
  • View 2k91
Molmil generated image of 2k91
ENHANCING THE ACTIVITY OF INSULIN BY STEREOSPECIFIC UNFOLDING
Descriptor:Insulin
Authors:Hua, Q.X., Xu, B., Huang, K., Hu, S.Q., Nakarawa, S., Jia, W.H., Philips, N.F.P., Wittaker, L., Wittaker, J., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2008-09-29
Release date:2008-11-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Enhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINS.
J.Biol.Chem., 284, 2009
2K9R
  • Download 2k9r
  • View 2k9r
Molmil generated image of 2k9r
ENHANCING THE ACTIVITY OF INSULIN BY STEREOSPECIFIC UNFOLDING
Descriptor:Insulin
Authors:Hua, Q.X., Xu, B., Huang, K., Hu, S.Q., Nakarawa, S., Jia, W.H., Philips, N.F.P., Wittaker, L., Wittaker, J., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2008-10-23
Release date:2008-11-11
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Enhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINS.
J.Biol.Chem., 284, 2009
2KJI
  • Download 2kji
  • View 2kji
Molmil generated image of 2kji
A DIVERGENT INS PROTEIN IN C. ELEGANS STRUCTURALLY RESEMBLE INSULIN AND ACTIVATES THE HUMAN INSULIN RECEPTOR
Descriptor:Probable insulin-like peptide beta-type 5
Authors:Hua, Q.X., Nakarawa, S.H., Wilken, R., Ramos, R.R., Jia, W.H., Bass, J., Weiss, M.A.
Deposit date:2009-05-28
Release date:2009-06-16
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Insulin worms its way into the spotlight.
Genes Dev., 17, 2003
1RWE
  • Download 1rwe
  • View 1rwe
Molmil generated image of 1rwe
ENHANCING THE ACTIVITY OF INSULIN AT RECEPTOR EDGE: CRYSTAL STRUCTURE AND PHOTO-CROSS-LINKING OF A8 ANALOGUES
Descriptor:insulin, Insulin, ZINC ION, ...
Authors:Wan, Z., Xu, B., Chu, Y.C., Li, B., Nakagawa, S.H., Qu, Y., Hu, S.Q., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2003-12-16
Release date:2005-02-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Enhancing the activity of insulin at the receptor interface: crystal structure and photo-cross-linking of A8 analogues.
Biochemistry, 43, 2004