Author results

3A8E
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THE STRUCTURE OF AXCESD OCTAMER COMPLEXED WITH CELLOPENTAOSE
Descriptor:Cellulose synthase operon protein D, CELLOPENTAOSE
Authors:Hu, S.Q., Tajima, K., Zhou, Y., Yao, M., Tanaka, I.
Deposit date:2009-10-05
Release date:2010-09-22
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of bacterial cellulose synthase subunit D octamer with four inner passageways
Proc.Natl.Acad.Sci.USA, 107, 2010
3AJ1
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THE STRUCTURE OF AXCESD OCTAMER (N-TERMINAL HIS-TAG) FROM ACETOBACTER XYLINUM
Descriptor:Cellulose synthase operon protein D
Authors:Hu, S.Q., Tajima, K., Zhou, Y., Tanaka, I., Yao, M.
Deposit date:2010-05-20
Release date:2010-10-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of bacterial cellulose synthase subunit D octamer with four inner passageways
Proc.Natl.Acad.Sci.USA, 107, 2010
3AJ2
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THE STRUCTURE OF AXCESD OCTAMER (C-TERMINAL HIS-TAG) FROM ACETOBACTER XYLINUM
Descriptor:Cellulose synthase operon protein D
Authors:Hu, S.Q., Tajima, K., Zhou, Y., Tanaka, I., Yao, M.
Deposit date:2010-05-20
Release date:2010-10-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of bacterial cellulose synthase subunit D octamer with four inner passageways
Proc.Natl.Acad.Sci.USA, 107, 2010
5ZVL
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CRYSTAL STRUCTURE OF WHEAT GLUTARREDOXIN
Descriptor:Glutaredoxin
Authors:Hu, S.Q., Sun, X.M., Chen, M.R.
Deposit date:2018-05-11
Release date:2019-03-13
Method:X-RAY DIFFRACTION (2.963 Å)
Cite:Crystal Structure of Wheat Glutaredoxin and Its Application in Improving the Processing Quality of Flour.
J. Agric. Food Chem., 66, 2018
3P2X
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INSULIN FIBRILLATION IS THE JANUS FACE OF INDUCED FIT. A CHIARAL CLAMP STABILIZES THE NATIVE STATE AT THE EXPENSE OF ACTIVITY
Descriptor:Insulin, ZINC ION, CHLORIDE ION, ...
Authors:Hua, Q.X., Wan, Z.L., Huang, K., Hu, S.Q., Phillip, N.F., Jia, W.H., Whittingham, J., Dodson, G.G., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2010-10-04
Release date:2011-11-23
Last modified:2014-10-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity
To be Published
3P33
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INSULIN FIBRILLATION IS THE JANUS FACE OF INDUCED FIT. A CHIRAL CLAMP STABILIZES THE NATIVE STATE AT THE EXPENSE OF ACTIVITY
Descriptor:Insulin, PHENOL, ZINC ION, ...
Authors:Hua, Q.X., Wan, Z.L., Huang, K., Hu, S.Q., Phillip, N.F., Jia, W.H., Whittingham, J., Dodson, G.G., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2010-10-04
Release date:2011-11-23
Last modified:2014-10-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity
To be Published
3ROV
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INSULIN'S BIOSYNTHESIS AND ACTIVITY HAVE OPPOSING STRUCTURAL REQUIREMENTS: A NEW FACTOR IN NEONATAL DIABETES MELLITUS
Descriptor:Insulin, PHENOL, ZINC ION, ...
Authors:Weiss, M.A., Wan, Z.L., Dodson, E.J., Liu, M., Xu, B., Hua, Q.X., Turkenburg, M., Whittingham, J., Nakagawa, S.H., Huang, K., Hu, S.Q., Jia, W.H., Wang, S.H., Brange, J., Whittaker, J., Arvan, P., Katsoyannis, P.G., Dodson, G.G.
Deposit date:2011-04-26
Release date:2012-05-02
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
To be Published
3V19
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FORESTALLING INSULIN FIBRILLATION BY INSERTION OF A CHIRAL CLAMP MECHANISM-BASED APPLICATION OF PROTEIN ENGINEERING TO GLOBAL HEALTH
Descriptor:Insulin, ZINC ION, CHLORIDE ION, ...
Authors:Wan, Z.L., Hua, Q.X., Wickramasinghe, N.P., Huang, K., Petkova, A.T., Hu, S.Q., Phillips, N.B., Yeh, I.J., Whittake, J., Ismail-Beigi, F., Katsoyyannis, P.G., Tycko, R., Weiss, M.A.
Deposit date:2011-12-09
Release date:2012-12-12
Method:X-RAY DIFFRACTION (2 Å)
Cite:Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health
To be Published
3V1G
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FORESTALLING INSULIN FIBRILLATION BY INSERTION OF A CHIRAL CLAMP MECHANISM-BASED APPLICATION OF PROTEIN ENGINEERING TO GLOBAL HEALTH
Descriptor:Insulin, ZINC ION, PHENOL, ...
Authors:Wan, Z.L., Hua, Q.X., Wickramasinghe, N.P., Huang, K., Petkova, A.T., Hu, S.Q., Phillips, N.B., Yeh, I.J., Whittake, J., Ismail-Beigi, F., Katsoyyannis, P.G., Tycko, R., Weiss, M.A.
Deposit date:2011-12-09
Release date:2012-12-12
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health
To be Published
5XWF
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CRYSTAL STRUCTURE OF CHITINASE (RMCHI1) FROM RHIZOMUCOR MIEHEI (SP3221/SAD)
Descriptor:Fungal chitinase from Rhizomucor miehei (SeMet-substituted proteins)
Authors:Jiang, Z.Q., Hu, S.Q., Liu, Y.C., Qin, Z., Yan, Q.J., Yang, S.Q.
Deposit date:2017-06-29
Release date:2018-07-04
Method:X-RAY DIFFRACTION (2.581 Å)
Cite:Crystal structure of chitinase (RmChi1) from Rhizomucor miehei (SP3221/SAD)
To Be Published
5XWQ
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CRYSTAL STRUCTURE OF CHITINASE (RMCHI1) FROM RHIZOMUCOR MIEHEI (SP P32 2 1, MR)
Descriptor:Fungal chitinase from Rhizomucor miehei (Native protein), MAGNESIUM ION
Authors:Jiang, Z.Q., Hu, S.Q., Liu, Y.C., Qin, Z., Yan, Q.J., Yang, S.Q.
Deposit date:2017-06-30
Release date:2018-07-04
Method:X-RAY DIFFRACTION (2.759 Å)
Cite:Crystal structure of chitinase (RmChi1) from Rhizomucor miehei (sp p32 2 1, native)
To Be Published
5YUQ
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THE HIGH RESOLUTION STRUCTURE OF CHITINASE (RMCHI1) FROM THE THERMOPHILIC FUNGUS RHIZOMUCOR MIEHEI (SP P1)
Descriptor:Chintase
Authors:Jiang, Z.Q., Hu, S.Q., Liu, Y.C., Qin, Z., Yan, Q.J., Yang, S.Q.
Deposit date:2017-11-23
Release date:2018-11-28
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:The high resolution structure of chitinase (RmChi1) from the thermophilic fungus Rhizomucor miehei (sp P1)
To Be Published
1T1K
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NMR STRUCTURE OF HUMAN INSULIN MUTANT HIS-B10-ASP, VAL-B12-ALA, PRO-B28-LYS, LYS-B29-PRO, 15 STRUCTURES
Descriptor:Insulin
Authors:Huang, K., Xu, B., Hu, S.Q., Chu, Y.C., Hua, Q.X., Whittaker, J., Nakagawa, S.H., De Meyts, P., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2004-04-16
Release date:2004-08-10
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:How Insulin Binds: the B-Chain alpha-Helix Contacts the L1 beta-Helix of the Insulin Receptor.
J.Mol.Biol., 341, 2004
1T1P
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NMR STRUCTURE OF HUMAN INSULIN MUTANT HIS-B10-ASP, VAL-B12-THR, PRO-B28-LYS, LYS-B29-PRO, 15 STRUCTURES
Descriptor:insulin, Insulin
Authors:Huang, K., Xu, B., Hu, S.Q., Chu, Y.C., Hua, Q.X., Whittaker, J., Nakagawa, S.H., De Meyts, P., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2004-04-16
Release date:2004-08-10
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:How Insulin Binds: the B-Chain alpha-Helix Contacts the L1 beta-Helix of the Insulin Receptor.
J.Mol.Biol., 341, 2004
1T1Q
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NMR STRUCTURE OF HUMAN INSULIN MUTANT HIS-B10-ASP, VAL-B12-ABA, PRO-B28-LYS, LYS-B29-PRO, 15 STRUCTURES
Descriptor:insulin, Insulin
Authors:Huang, K., Xu, B., Hu, S.Q., Chu, Y.C., Hua, Q.X., Whittaker, J., Nakagawa, S.H., De Meyts, P., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2004-04-16
Release date:2004-08-10
Last modified:2012-03-28
Method:SOLUTION NMR
Cite:How Insulin Binds: the B-Chain alpha-Helix Contacts the L1 beta-Helix of the Insulin Receptor.
J.Mol.Biol., 341, 2004
3BXQ
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THE STRUCTURE OF A MUTANT INSULIN UNCOUPLES RECEPTOR BINDING FROM PROTEIN ALLOSTERY. AN ELECTROSTATIC BLOCK TO THE TR TRANSITION
Descriptor:insulin A chain, insulin B chain, ZINC ION
Authors:Wan, Z.L., Huang, K., Hu, S.Q., Whittaker, J., Weiss, M.A.
Deposit date:2008-01-14
Release date:2008-05-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Design of an active ultrastable single-chain insulin analog: synthesis, structure, and therapeutic implications.
J.Biol.Chem., 283, 2008
3JSD
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INSULIN'S BIOSYNTHESIS AND ACTIVITY HAVE OPPOSING STRUCTURAL REQUIREMENTS: A NEW FACTOR IN NEONATAL DIABETES MELLITUS
Descriptor:Insulin A chain, Insulin B chain, ZINC ION, ...
Authors:Weiss, M.A., Wan, Z.L., Dodson, E.J., Liu, M., Xu, B., Hua, Q.X., Turkenburg, M., Whittingham, J., Nakagawa, S.H., Huang, K., Hu, S.Q., Jia, W.H., Wang, S.H., Brange, J., Whittaker, J., Arvan, P., Katsoyannis, P.G., Dodson, G.G.
Deposit date:2009-09-10
Release date:2010-09-15
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
To be Published
3KQ6
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ENHANCING THE THERAPEUTIC PROPERTIES OF A PROTEIN BY A DESIGNED ZINC-BINDING SITE, STRUCTURAL PRINCIPLES OF A NOVEL LONG-ACTING INSULIN ANALOG
Descriptor:Insulin A chain, Insulin B chain, ZINC ION, ...
Authors:Wan, Z.L., Hu, S.Q., Whittaker, L., Phillips, N.B., Whittake, J., Ismail-Beigi, F., Weiss, M.A.
Deposit date:2009-11-17
Release date:2010-02-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Supramolecular protein engineering: design of zinc-stapled insulin hexamers as a long acting depot.
J.Biol.Chem., 285, 2010
1RWE
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ENHANCING THE ACTIVITY OF INSULIN AT RECEPTOR EDGE: CRYSTAL STRUCTURE AND PHOTO-CROSS-LINKING OF A8 ANALOGUES
Descriptor:insulin, Insulin, ZINC ION, ...
Authors:Wan, Z., Xu, B., Chu, Y.C., Li, B., Nakagawa, S.H., Qu, Y., Hu, S.Q., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2003-12-16
Release date:2005-02-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Enhancing the activity of insulin at the receptor interface: crystal structure and photo-cross-linking of A8 analogues.
Biochemistry, 43, 2004
1SJT
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MINI-PROINSULIN, TWO CHAIN INSULIN ANALOG MUTANT: DES B30, HIS(B 10)ASP, PRO(B 28)ASP, NMR, 20 STRUCTURES
Descriptor:PROINSULIN
Authors:Hua, Q.X., Hu, S.Q., Jia, W.H., Chu, Y.C., Burke, G.T., Wang, S.H., Katsoyannis, P.G., Weiss, M.A.
Deposit date:1997-10-09
Release date:1998-03-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Mini-proinsulin and mini-IGF-I: homologous protein sequences encoding non-homologous structures.
J.Mol.Biol., 277, 1998
1SJU
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MINI-PROINSULIN, SINGLE CHAIN INSULIN ANALOG MUTANT: DES B30, HIS(B 10)ASP, PRO(B 28)ASP AND PEPTIDE BOND BETWEEN LYS B 29 AND GLY A 1, NMR, 20 STRUCTURES
Descriptor:PROINSULIN
Authors:Hua, Q.X., Hu, S.Q., Jia, W.H., Chu, Y.C., Burke, G.T., Wang, S.H., Katsoyannis, P.G., Weiss, M.A.
Deposit date:1997-10-09
Release date:1998-03-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Mini-proinsulin and mini-IGF-I: homologous protein sequences encoding non-homologous structures.
J.Mol.Biol., 277, 1998
1VKT
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HUMAN INSULIN TWO DISULFIDE MODEL, NMR, 10 STRUCTURES
Descriptor:INSULIN
Authors:Hua, Q.X., Hu, S.Q., Frank, B.H., Jia, W.H., Chu, Y.C., Wang, S.H., Burke, G.T., Katsoyannis, P.G., Weiss, M.A.
Deposit date:1996-10-14
Release date:1997-04-01
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Mapping the functional surface of insulin by design: structure and function of a novel A-chain analogue.
J.Mol.Biol., 264, 1996
1XW7
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DIABETES-ASSOCIATED MUTATIONS IN HUMAN INSULIN: CRYSTAL STRUCTURE AND PHOTO-CROSS-LINKING STUDIES OF A-CHAIN VARIANT INSULIN WAKAYAMA
Descriptor:Insulin, PHENOL, ZINC ION, ...
Authors:Wan, Z.L., Huang, K., Xu, B., Chu, Y.C., Hu, S.Q., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2004-10-29
Release date:2005-04-12
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Diabetes-associated mutations in human insulin: crystal structure and photo-cross-linking studies of a-chain variant insulin wakayama
Biochemistry, 44, 2005
2H67
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NMR STRUCTURE OF HUMAN INSULIN MUTANT HIS-B5-ALA, HIS-B10-ASP PRO-B28-LYS, LYS-B29-PRO, 20 STRUCTURES
Descriptor:Insulin A chain, Insulin B chain
Authors:Hua, Q.X., Liu, M., Hu, S.Q., Jia, W., Arvan, P., Weiss, M.A.
Deposit date:2006-05-30
Release date:2006-07-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A Conserved Histidine in Insulin Is Required for the Foldability of Human Proinsulin: Structure and function of an Alab5 analog.
J.Biol.Chem., 281, 2006
2HH4
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NMR STRUCTURE OF HUMAN INSULIN MUTANT GLY-B8-D-SER, HIS-B10-ASP PRO-B28-LYS, LYS-B29-PRO, 20 STRUCTURES
Descriptor:insulin A chain, insulin B chain
Authors:Hua, Q.X., Nakagawa, S., Hu, S.Q., Jia, W., Weiss, M.A.
Deposit date:2006-06-27
Release date:2006-07-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Toward the Active Conformation of Insulin: Stereospecific modulation of a structural switch in the B chain.
J.Biol.Chem., 281, 2006
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