Protein Data Bank Japan

Author results

S-NITROSYLATED PHD2 (GSNO SOAKED) IN COMPLEX WITH ZN(II) AND UN9
Descriptor:	EGL NINE HOMOLOG 1, ZINC ION, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE
Authors:	Chowdhury, R., Clifton, I.J., Schofield, C.J.
Deposit date:	2010-12-18
Release date:	2010-12-29
Last modified:	2019-01-30
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Studies on the Reaction of Nitric Oxide with the Hypoxia-Inducible Factor Prolyl Hydroxylase Domain 2 (Egln1) J.Mol.Biol., 410, 2011

2Y34

S-NITROSYLATED PHD2 (NO EXPOSED) IN COMPLEX WITH FE(II) AND UN9
Descriptor:	EGL NINE HOMOLOG 1, FE (II) ION, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE
Authors:	Chowdhury, R., McDonough, M.A., Schofield, C.J.
Deposit date:	2010-12-18
Release date:	2010-12-29
Last modified:	2019-01-30
Method:	X-RAY DIFFRACTION (2.01 Å)
Cite:	Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1). J. Mol. Biol., 410, 2011

5L9B

HIF PROLYL HYDROXYLASE 2 (PHD2/ EGLN1) IN COMPLEX WITH 2-OXOGLUTARATE (2OG) AND HIF-1ALPHA CODD (556-574)
Descriptor:	Egl nine homolog 1, Hypoxia-inducible factor 1-alpha, MANGANESE (II) ION, ...
Authors:	Chowdhury, R., Schofield, C.J.
Deposit date:	2016-06-10
Release date:	2016-08-31
Last modified:	2016-09-07
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5L9R

HIF PROLYL HYDROXYLASE 2 (PHD2/ EGLN1) IN COMPLEX WITH N-OXALYLGLYCINE (NOG)
Descriptor:	Egl nine homolog 1, MANGANESE (II) ION, N-OXALYLGLYCINE, ...
Authors:	Chowdhury, R., Schofield, C.J.
Deposit date:	2016-06-10
Release date:	2016-08-31
Last modified:	2017-11-29
Method:	X-RAY DIFFRACTION (1.81 Å)
Cite:	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5LA9

HIF PROLYL HYDROXYLASE 2 (PHD2-R281C/V314C) CROSS-LINKED TO HIF-1ALPHA NODD-L397C/D412C AND N-OXALYLGLYCINE (NOG) (COMPLEX-2)
Descriptor:	Egl nine homolog 1, Hypoxia-inducible factor 1-alpha, MANGANESE (II) ION, ...
Authors:	Chowdhury, R., Schofield, C.J.
Deposit date:	2016-06-14
Release date:	2016-08-31
Last modified:	2016-09-07
Method:	X-RAY DIFFRACTION (2.813 Å)
Cite:	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5LAS

HIF PROLYL HYDROXYLASE 2 (PHD2-R281C/P317C/R396T) CROSS-LINKED TO HIF-1ALPHA NODD-L397C/D412C AND N-OXALYLGLYCINE (NOG) (COMPLEX-3)
Descriptor:	Egl nine homolog 1, Hypoxia-inducible factor 1-alpha, MANGANESE (II) ION, ...
Authors:	Chowdhury, R., Schofield, C.J.
Deposit date:	2016-06-14
Release date:	2016-08-31
Last modified:	2017-11-29
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5LAT

HIF PROLYL HYDROXYLASE 2 (PHD2/EGLN1) P317R VARIANT IN COMPLEX WITH MN(II) AND N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE (IOX3/UN9)
Descriptor:	Egl nine homolog 1, MANGANESE (II) ION, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE, ...
Authors:	Chowdhury, R., Schofield, C.J.
Deposit date:	2016-06-15
Release date:	2016-08-31
Last modified:	2017-11-29
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5LB6

HIF PROLYL HYDROXYLASE 2 (PHD2/EGLN1) R371H VARIANT IN COMPLEX WITH MN(II) AND N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE (IOX3/UN9)
Descriptor:	Egl nine homolog 1, MANGANESE (II) ION, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE, ...
Authors:	Chowdhury, R., Schofield, C.J.
Deposit date:	2016-06-15
Release date:	2016-08-31
Last modified:	2016-09-07
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5LBB

HIF PROLYL HYDROXYLASE 2 (PHD2/EGLN1) R396T VARIANT IN COMPLEX WITH MN(II) AND N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE (IOX3/UN9)
Descriptor:	Egl nine homolog 1, MANGANESE (II) ION, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE, ...
Authors:	Chowdhury, R., Schofield, C.J.
Deposit date:	2016-06-15
Release date:	2016-08-31
Last modified:	2016-09-07
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5LBC

HIF PROLYL HYDROXYLASE 2 (PHD2/EGLN1) I280V/R281L/I292V VARIANT IN COMPLEX WITH MN(II) AND N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE (IOX3/FG2216)
Descriptor:	Egl nine homolog 1, MANGANESE (II) ION, CHLORIDE ION, ...
Authors:	Chowdhury, R., Schofield, C.J.
Deposit date:	2016-06-15
Release date:	2016-08-31
Last modified:	2016-09-07
Method:	X-RAY DIFFRACTION (1.816 Å)
Cite:	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5LBE

HIF PROLYL HYDROXYLASE 2 (PHD2/EGLN1) G294E VARIANT IN COMPLEX WITH MN(II) AND N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE (IOX3/FG2216)
Descriptor:	Egl nine homolog 1, MANGANESE (II) ION, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE, ...
Authors:	Chowdhury, R., Schofield, C.J.
Deposit date:	2016-06-15
Release date:	2016-08-31
Last modified:	2017-11-29
Method:	X-RAY DIFFRACTION (1.749 Å)
Cite:	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5LBF

HIF PROLYL HYDROXYLASE 2 (PHD2/EGLN1) K293K/G294E VARIANT IN COMPLEX WITH MN(II) AND N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE (IOX3/FG2216)
Descriptor:	Egl nine homolog 1, MANGANESE (II) ION, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE, ...
Authors:	Chowdhury, R., Schofield, C.J.
Deposit date:	2016-06-16
Release date:	2016-08-31
Last modified:	2017-11-29
Method:	X-RAY DIFFRACTION (1.8995 Å)
Cite:	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

4BU2

60S RIBOSOMAL PROTEIN L27A HISTIDINE HYDROXYLASE (MINA53) IN COMPLEX WITH NI(II) AND 2-OXOGLUTARATE (2OG)
Descriptor:	BIFUNCTIONAL LYSINE-SPECIFIC DEMETHYLASE AND HISTIDYL-HYDROXYLASE MINA, NICKEL (II) ION, 2-OXOGLUTARIC ACID, ...
Authors:	Chowdhury, R., Clifton, I.J., McDonough, M.A., Ng, S.S., Pilka, E., Oppermann, U., Schofield, C.J.
Deposit date:	2013-06-19
Release date:	2014-05-14
Last modified:	2019-02-06
Method:	X-RAY DIFFRACTION (2.78 Å)
Cite:	Ribosomal oxygenases are structurally conserved from prokaryotes to humans. Nature, 510, 2014

4BXF

60S RIBOSOMAL PROTEIN L27A HISTIDINE HYDROXYLASE (MINA53 Y209C) IN COMPLEX WITH MN(II), 2-OXOGLUTARATE (2OG) AND 60S RIBOSOMAL PROTEIN L27A (RPL27A G37C) PEPTIDE FRAGMENT
Descriptor:	BIFUNCTIONAL LYSINE-SPECIFIC DEMETHYLASE AND HISTIDYL-HYDROXYLASE MINA, 60S RIBOSOMAL PROTEIN L27A, MANGANESE (II) ION, ...
Authors:	Chowdhury, R., Schofield, C.J.
Deposit date:	2013-07-10
Release date:	2014-05-14
Last modified:	2019-01-30
Method:	X-RAY DIFFRACTION (2.05 Å)
Cite:	Ribosomal oxygenases are structurally conserved from prokaryotes to humans. Nature, 510, 2014

4CCJ

60S RIBOSOMAL PROTEIN L8 HISTIDINE HYDROXYLASE (NO66) IN APO FORM
Descriptor:	BIFUNCTIONAL LYSINE-SPECIFIC DEMETHYLASE AND HISTIDYL-HYDROXYLASE NO66, 1,2-ETHANEDIOL
Authors:	Chowdhury, R., Ge, W., Clifton, I.J., Schofield, C.J.
Deposit date:	2013-10-23
Release date:	2014-05-14
Last modified:	2019-05-08
Method:	X-RAY DIFFRACTION (2.15 Å)
Cite:	Ribosomal oxygenases are structurally conserved from prokaryotes to humans. Nature, 510, 2014

4CCK

60S RIBOSOMAL PROTEIN L8 HISTIDINE HYDROXYLASE (NO66) IN COMPLEX WITH MN(II) AND N-OXALYLGLYCINE (NOG)
Descriptor:	BIFUNCTIONAL LYSINE-SPECIFIC DEMETHYLASE AND HISTIDYL-HYDROXYLASE NO66, MANGANESE (II) ION, N-OXALYLGLYCINE, ...
Authors:	Chowdhury, R., Ge, W., Clifton, I.J., Schofield, C.J.
Deposit date:	2013-10-23
Release date:	2014-05-14
Last modified:	2019-02-06
Method:	X-RAY DIFFRACTION (2.15 Å)
Cite:	Ribosomal oxygenases are structurally conserved from prokaryotes to humans. Nature, 510, 2014

4CCM

60S RIBOSOMAL PROTEIN L8 HISTIDINE HYDROXYLASE (NO66) IN COMPLEX WITH MN(II), N-OXALYLGLYCINE (NOG) AND 60S RIBOSOMAL PROTEIN L8 (RPL8 G220C) PEPTIDE FRAGMENT (COMPLEX-1)
Descriptor:	BIFUNCTIONAL LYSINE-SPECIFIC DEMETHYLASE AND HISTIDYL-HYDROXYLASE NO66, 60S RIBOSOMAL PROTEIN L8, MANGANESE (II) ION, ...
Authors:	Chowdhury, R., Schofield, C.J.
Deposit date:	2013-10-23
Release date:	2014-05-14
Last modified:	2019-02-06
Method:	X-RAY DIFFRACTION (2.51 Å)
Cite:	Ribosomal oxygenases are structurally conserved from prokaryotes to humans. Nature, 510, 2014

4CCN

60S RIBOSOMAL PROTEIN L8 HISTIDINE HYDROXYLASE (NO66 L299C/C300S) IN COMPLEX WITH MN(II), N-OXALYLGLYCINE (NOG) AND 60S RIBOSOMAL PROTEIN L8 (RPL8 G220C) PEPTIDE FRAGMENT (COMPLEX-2)
Descriptor:	BIFUNCTIONAL LYSINE-SPECIFIC DEMETHYLASE AND HISTIDYL-HYDROXYLASE NO66, 60S RIBOSOMAL PROTEIN L8, MANGANESE (II) ION, ...
Authors:	Chowdhury, R., Schofield, C.J.
Deposit date:	2013-10-23
Release date:	2014-05-14
Last modified:	2019-02-06
Method:	X-RAY DIFFRACTION (2.23 Å)
Cite:	Ribosomal oxygenases are structurally conserved from prokaryotes to humans. Nature, 510, 2014

4CCO

60S RIBOSOMAL PROTEIN L8 HISTIDINE HYDROXYLASE (NO66 S373C) IN COMPLEX WITH MN(II), N-OXALYLGLYCINE (NOG) AND 60S RIBOSOMAL PROTEIN L8 (RPL8 G214C) PEPTIDE FRAGMENT (COMPLEX-3)
Descriptor:	BIFUNCTIONAL LYSINE-SPECIFIC DEMETHYLASE AND HISTIDYL-HYDROXYLASE NO66, 60S RIBOSOMAL PROTEIN L8, MANGANESE (II) ION, ...
Authors:	Chowdhury, R., Schofield, C.J.
Deposit date:	2013-10-23
Release date:	2014-05-14
Last modified:	2019-02-06
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Ribosomal oxygenases are structurally conserved from prokaryotes to humans. Nature, 510, 2014

3HQR

PHD2:MN:NOG:HIF1-ALPHA SUBSTRATE COMPLEX
Descriptor:	Egl nine homolog 1, Hypoxia-inducible factor 1 alpha, MANGANESE (II) ION, ...
Authors:	Chowdhury, R., McDonough, M.A., Schofield, C.J.
Deposit date:	2009-06-08
Release date:	2009-07-28
Last modified:	2017-11-01
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases Structure, 17, 2009

3HQU

PHD2:FE:UN9:PARTIAL HIF1-ALPHA SUBSTRATE COMPLEX
Descriptor:	Egl nine homolog 1, Hypoxia-inducible factor 1 alpha, FE (II) ION, ...
Authors:	Chowdhury, R., McDonough, M.A., Schofield, C.J.
Deposit date:	2009-06-08
Release date:	2009-07-28
Last modified:	2017-11-01
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases Structure, 17, 2009

5L9V

HIF PROLYL HYDROXYLASE 2 (PHD2-R281C/P317C) CROSS-LINKED TO HIF-1ALPHA NODD-L397C/D412C AND N-OXALYLGLYCINE (NOG) (COMPLEX-1)
Descriptor:	Egl nine homolog 1, Hypoxia-inducible factor 1-alpha, MANGANESE (II) ION, ...
Authors:	Chowdhury, R., Schofield, C.J.
Deposit date:	2016-06-11
Release date:	2016-08-31
Last modified:	2017-11-29
Method:	X-RAY DIFFRACTION (1.829 Å)
Cite:	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

2YBK

JMJD2A COMPLEXED WITH R-2-HYDROXYGLUTARATE
Descriptor:	LYSINE-SPECIFIC DEMETHYLASE 4A, NICKEL (II) ION, ZINC ION, ...
Authors:	Chowdhury, R., McDonough, M.A., Schofield, C.J.
Deposit date:	2011-03-08
Release date:	2011-04-06
Last modified:	2019-01-30
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases. EMBO Rep., 12, 2011

2YBP

JMJD2A COMPLEXED WITH R-2-HYDROXYGLUTARATE AND HISTONE H3K36ME3 PEPTIDE (30-41)
Descriptor:	LYSINE-SPECIFIC DEMETHYLASE 4A, HISTONE H3.1T, NICKEL (II) ION, ...
Authors:	Chowdhury, R., McDonough, M.A., Schofield, C.J.
Deposit date:	2011-03-09
Release date:	2011-03-30
Last modified:	2019-01-30
Method:	X-RAY DIFFRACTION (2.02 Å)
Cite:	The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases. EMBO Rep., 12, 2011

2YBS

JMJD2A COMPLEXED WITH S-2-HYDROXYGLUTARATE AND HISTONE H3K36ME3 PEPTIDE (30-41)
Descriptor:	LYSINE-SPECIFIC DEMETHYLASE 4A, HISTONE H3.1T, NICKEL (II) ION, ...
Authors:	Chowdhury, R., Schofield, C.J.
Deposit date:	2011-03-10
Release date:	2011-03-30
Last modified:	2019-01-30
Method:	X-RAY DIFFRACTION (2.32 Å)
Cite:	The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases. EMBO Rep., 12, 2011

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