6I7Q

Structure of pVHL-elongin B-elongin C (VCB) in complex with hydroxylated-HIF-2alpha (523-542) in the C2221 form

Summary for 6I7Q

• Entry DOI: 10.2210/pdb6i7q/pdb
• Descriptor: Elongin-B, Elongin-C, Endothelial PAS domain-containing protein 1, ... (6 entities in total)
• Functional Keywords: e3 ubiquitin ligase, gene regulation, von hippel lindau, prolyl hydroxylation, hif, tumor suppressor, cancer, proteosomal degradation, ubiquitin
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 45076.06

Authors

Chowdhury, R.,Aguilera, L.S.,Schofield, C.J. (deposition date: 2018-11-17, release date: 2019-11-27, Last modification date: 2024-01-24)

• Primary citation: Chowdhury, R.,Schofield, C.J.; HIF-2alpha-pVHL-elongin B-elongin C complex; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.798 Å)