6I7Q
Structure of pVHL-elongin B-elongin C (VCB) in complex with hydroxylated-HIF-2alpha (523-542) in the C2221 form
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Elongin-B | polymer | 118 | 13179.8 | 1 | UniProt (Q15370) Pfam (PF00240) | Homo sapiens (Human) | EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2 |
| 2 | B (C) | Elongin-C | polymer | 97 | 10930.5 | 1 | UniProt (Q2KII4) Pfam (PF03931) | Bos taurus (Bovine) | EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1 |
| 3 | C (H) | Endothelial PAS domain-containing protein 1 | polymer | 20 | 2315.5 | 1 | UniProt (Q99814) Pfam (PF11413) | Homo sapiens | EPAS-1,Basic-helix-loop-helix-PAS protein MOP2,Class E basic helix-loop-helix protein 73,bHLHe73,HIF-1-alpha-like factor,HLF,Hypoxia-inducible factor 2-alpha,HIF2-alpha,Member of PAS protein 2,PAS domain-containing protein 2 |
| 4 | D (V) | von Hippel-Lindau disease tumor suppressor | polymer | 160 | 18558.2 | 1 | UniProt (P40337) Pfam (PF01847) Pfam (PF17211) | Homo sapiens (Human) | Protein G7,pVHL |
| 5 | E (V) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | F, G, H, I (B, C, H, V) | water | water | 18.0 | 320 | Chemie (HOH) |
Sequence modifications
C: 17 - 112 (UniProt: Q2KII4)
H: 523 - 542 (UniProt: Q99814)
| PDB | External Database | Details |
|---|---|---|
| Ser 16 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Cys 542 | Leu 542 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 44984.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 92.1 | |
| All* | Total formula weight | 45076.1 |
