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3HQU

PHD2:Fe:UN9:partial HIF1-alpha substrate complex

Summary for 3HQU
Entry DOI10.2210/pdb3hqu/pdb
Related2G1M 3HQR
DescriptorEgl nine homolog 1, Hypoxia-inducible factor 1 alpha, FE (II) ION, ... (5 entities in total)
Functional Keywordsdouble stranded beta-helix, alternative splicing, congenital erythrocytosis, dioxygenase, disease mutation, iron, metal-binding, oxidoreductase, vitamin c, zinc, zinc-finger, activator, cytoplasm, dna-binding, hydroxylation, isopeptide bond, nucleus, phosphoprotein, polymorphism, s-nitrosylation, transcription, transcription regulation, ubl conjugation, oxidoreductase-transcription complex, oxidoreductase/transcription
Biological sourceHomo sapiens (human)
More
Cellular locationCytoplasm : Q9GZT9 Q16665
Total number of polymer chains2
Total formula weight29888.11
Authors
Chowdhury, R.,McDonough, M.A.,Schofield, C.J. (deposition date: 2009-06-08, release date: 2009-07-28, Last modification date: 2023-11-01)
Primary citationChowdhury, R.,McDonough, M.A.,Mecinovic, J.,Loenarz, C.,Flashman, E.,Hewitson, K.S.,Domene, C.,Schofield, C.J.
Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases
Structure, 17:981-989, 2009
Cited by
PubMed: 19604478
DOI: 10.1016/j.str.2009.06.002
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation

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