3HQU

PHD2:Fe:UN9:partial HIF1-alpha substrate complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005506	molecular_function	iron ion binding
A	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A	0031418	molecular_function	L-ascorbic acid binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE2 A 450

Chain	Residue
A	HIS313
A	ASP315
A	HIS374
A	UN9500
A	HOH1012

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site_id	AC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE UN9 A 500

Chain	Residue
A	HIS313
A	ASP315
A	TYR329
A	LEU343
A	HIS374
A	VAL376
A	ARG383
A	ARG398
A	VAL401
A	FE2450
A	HOH1012
A	HOH1063
A	ASP254
A	MET299
A	TYR303
A	TYR310

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: 4-hydroxyproline => ECO:0000269|PubMed:11292861, ECO:0000269|PubMed:11566883, ECO:0000269|PubMed:12351678, ECO:0000269|PubMed:25974097

Chain	Residue	Details
S	PRO564
A	ASP315
A	HIS374

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000305|PubMed:19604478

Chain	Residue	Details
A	ARG383

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site_id	SWS_FT_FI3
Number of Residues	5
Details	MOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:21601578

Chain	Residue	Details
A	CYS201
A	CYS208
A	CYS302
A	CYS323
A	CYS326

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