3HQR

PHD2:Mn:NOG:HIF1-alpha substrate complex

Summary for 3HQR

Entry DOI	10.2210/pdb3hqr/pdb
Related	2G1M 3HQU
Descriptor	Egl nine homolog 1, Hypoxia-inducible factor 1 alpha, MANGANESE (II) ION, ... (5 entities in total)
Functional Keywords	double stranded beta-helix, alternative splicing, congenital erythrocytosis, dioxygenase, disease mutation, iron, metal-binding, oxidoreductase, vitamin c, zinc, zinc-finger, activator, cytoplasm, dna-binding, hydroxylation, isopeptide bond, nucleus, phosphoprotein, polymorphism, s-nitrosylation, transcription, transcription regulation, ubl conjugation, oxidoreductase-transcription complex, oxidoreductase/transcription
Biological source	Homo sapiens (human) More
Cellular location	Cytoplasm : Q9GZT9 Q16665
Total number of polymer chains	2
Total formula weight	29667.51
Authors	Chowdhury, R.,McDonough, M.A.,Schofield, C.J. (deposition date: 2009-06-08, release date: 2009-07-28, Last modification date: 2023-11-01)
Primary citation	Chowdhury, R.,McDonough, M.A.,Mecinovic, J.,Loenarz, C.,Flashman, E.,Hewitson, K.S.,Domene, C.,Schofield, C.J. Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases Structure, 17:981-989, 2009 Cited by PubMed: 19604478 DOI: 10.1016/j.str.2009.06.002 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation