PHD2:Mn:NOG:HIF1-alpha substrate complex

Summary for 3HQR

Related3HQU 2G1M
DescriptorEgl nine homolog 1, Hypoxia-inducible factor 1 alpha, MANGANESE (II) ION, ... (5 entities in total)
Functional Keywordsdouble stranded beta-helix, alternative splicing, congenital erythrocytosis, dioxygenase, disease mutation, iron, metal-binding, oxidoreductase, vitamin c, zinc, zinc-finger, activator, cytoplasm, dna-binding, hydroxylation, isopeptide bond, nucleus, phosphoprotein, polymorphism, s-nitrosylation, transcription, transcription regulation, ubl conjugation, oxidoreductase-transcription complex, oxidoreductase/transcription
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm  Q9GZT9 Q16665
Total number of polymer chains2
Total molecular weight29667.51
Chowdhury, R.,McDonough, M.A.,Schofield, C.J. (deposition date: 2009-06-08, release date: 2009-07-28, Last modification date: 2017-11-01)
Primary citation
Chowdhury, R.,McDonough, M.A.,Mecinovic, J.,Loenarz, C.,Flashman, E.,Hewitson, K.S.,Domene, C.,Schofield, C.J.
Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases
Structure, 17:981-989, 2009
PubMed: 19604478 (PDB entries with the same primary citation)
DOI: 10.1016/j.str.2009.06.002
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers36 1.3% 5.5% 7.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-12-02