3HQR
PHD2:Mn:NOG:HIF1-alpha substrate complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Egl nine homolog 1 | polymer | 246 | 27439.2 | 1 | UniProt (Q9GZT9) Pfam (PF13640) | Homo sapiens (human) | Prolyl hydroxylase, Hypoxia-inducible factor prolyl hydroxylase 2, HIF-prolyl hydroxylase 2, HIF-PH2, HPH-2, Prolyl hydroxylase domain-containing protein 2, PHD2, SM-20 |
| 2 | B (S) | Hypoxia-inducible factor 1 alpha | polymer | 17 | 2026.3 | 1 | UniProt (Q16665) Pfam (PF11413) | Homo sapiens | HIF-1 alpha, HIF1 alpha, ARNT-interacting protein, Member of PAS protein 1, Basic-helix-loop-helix-PAS protein MOP1 |
| 3 | C (A) | MANGANESE (II) ION | non-polymer | 54.9 | 1 | Chemie (MN) | |||
| 4 | D (A) | N-OXALYLGLYCINE | non-polymer | 147.1 | 1 | Chemie (OGA) | |||
| 5 | E (A) | water | water | 18.0 | 151 | Chemie (HOH) |
Sequence modifications
A: 181 - 426 (UniProt: Q9GZT9)
| PDB | External Database | Details |
|---|---|---|
| Ala 398 | Arg 398 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 29465.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 202.0 | |
| All* | Total formula weight | 29667.5 |
