2G1M
Cellular Oxygen Sensing: Crystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2)
Summary for 2G1M
Entry DOI | 10.2210/pdb2g1m/pdb |
Related | 2G19 |
Descriptor | Egl nine homolog 1, FE (II) ION, N-[(4-HYDROXY-8-IODOISOQUINOLIN-3-YL)CARBONYL]GLYCINE, ... (4 entities in total) |
Functional Keywords | phd2, hif, dsbh, oxygenase, transcription, hypoxia, 2-oxoglutarate, prolyl hydroxylase, hydroxylase, elgn, hph, sm-20, transcription activator, inhibitor, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : Q9GZT9 |
Total number of polymer chains | 1 |
Total formula weight | 27953.27 |
Authors | Mcdonough, M.A.,Schofield, C.J. (deposition date: 2006-02-14, release date: 2006-06-13, Last modification date: 2024-02-14) |
Primary citation | McDonough, M.A.,Li, V.,Flashman, E.,Chowdhury, R.,Mohr, C.,Lienard, B.M.,Zondlo, J.,Oldham, N.J.,Clifton, I.J.,Lewis, J.,McNeill, L.A.,Kurzeja, R.J.,Hewitson, K.S.,Yang, E.,Jordan, S.,Syed, R.S.,Schofield, C.J. Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2). Proc.Natl.Acad.Sci.Usa, 103:9814-9819, 2006 Cited by PubMed: 16782814DOI: 10.1073/pnas.0601283103 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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