Cellular Oxygen Sensing: Crystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2)

Summary for 2G1M

DescriptorEgl nine homolog 1, FE (II) ION, N-[(4-HYDROXY-8-IODOISOQUINOLIN-3-YL)CARBONYL]GLYCINE, ... (4 entities in total)
Functional Keywordsphd2, hif, dsbh, oxygenase, transcription, hypoxia, 2-oxoglutarate, prolyl hydroxylase, hydroxylase, elgn, hph, sm-20, transcription activator, inhibitor, oxidoreductase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm  Q9GZT9
Total number of polymer chains1
Total molecular weight27953.27
Mcdonough, M.A.,Schofield, C.J. (deposition date: 2006-02-14, release date: 2006-06-13, Last modification date: 2017-10-18)
Primary citation
McDonough, M.A.,Li, V.,Flashman, E.,Chowdhury, R.,Mohr, C.,Lienard, B.M.,Zondlo, J.,Oldham, N.J.,Clifton, I.J.,Lewis, J.,McNeill, L.A.,Kurzeja, R.J.,Hewitson, K.S.,Yang, E.,Jordan, S.,Syed, R.S.,Schofield, C.J.
Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2).
Proc.Natl.Acad.Sci.Usa, 103:9814-9819, 2006
PubMed: 16782814 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.0601283103
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2928 0.5% 3.1% 2.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-11-25