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2G19

Cellular Oxygen Sensing: Crystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2)

Summary for 2G19
Entry DOI10.2210/pdb2g19/pdb
DescriptorEgl nine homolog 1, FE (II) ION, N-[(4-HYDROXY-8-IODOISOQUINOLIN-3-YL)CARBONYL]GLYCINE, ... (4 entities in total)
Functional Keywordsphd2, hif, dsbh, oxygenase, transcription, hypoxia, 2-oxoglutarate, prolyl hydroxylase, hydroxylase, egln, hph, oxidoreductase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm : Q9GZT9
Total number of polymer chains1
Total formula weight27977.35
Authors
Syed, R.S.,Li, V. (deposition date: 2006-02-14, release date: 2006-06-13, Last modification date: 2024-02-14)
Primary citationMcDonough, M.A.,Li, V.,Flashman, E.,Chowdhury, R.,Mohr, C.,Lienard, B.M.,Zondlo, J.,Oldham, N.J.,Clifton, I.J.,Lewis, J.,McNeill, L.A.,Kurzeja, R.J.,Hewitson, K.S.,Yang, E.,Jordan, S.,Syed, R.S.,Schofield, C.J.
Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2).
Proc.Natl.Acad.Sci.Usa, 103:9814-9819, 2006
Cited by
PubMed: 16782814
DOI: 10.1073/pnas.0601283103
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.7 Å)
Structure validation

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