2G19
Cellular Oxygen Sensing: Crystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Egl nine homolog 1 | polymer | 244 | 27549.4 | 1 | UniProt (Q9GZT9) Pfam (PF13640) | Homo sapiens (human) | Hypoxia-inducible factor prolyl hydroxylase 2, HIF-prolyl hydroxylase 2, HIF-PH2, HPH-2, Prolyl hydroxylase domain-containing protein 2, PHD2, SM-20 |
| 2 | B (A) | FE (II) ION | non-polymer | 55.8 | 1 | Chemie (FE2) | |||
| 3 | C (A) | N-[(4-HYDROXY-8-IODOISOQUINOLIN-3-YL)CARBONYL]GLYCINE | non-polymer | 372.1 | 1 | Chemie (4HG) | |||
| 4 | D (A) | water | water | 18.0 | 135 | Chemie (HOH) |
Sequence modifications
A: 180 - 417 (UniProt: Q9GZT9)
| PDB | External Database | Details |
|---|---|---|
| His 418 | - | expression tag |
| His 419 | - | expression tag |
| His 420 | - | expression tag |
| His 421 | - | expression tag |
| His 422 | - | expression tag |
| His 423 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 27549.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 428.0 | |
| All* | Total formula weight | 27977.4 |
