4CCN

60S ribosomal protein L8 histidine hydroxylase (NO66 L299C/C300S) in complex with Mn(II), N-oxalylglycine (NOG) and 60S ribosomal protein L8 (RPL8 G220C) peptide fragment (complex-2)

Summary for 4CCN

Related2XDV 4BU2 4BXF 4CCJ 4CCK 4CCM 4CCO 4DIQ
DescriptorBIFUNCTIONAL LYSINE-SPECIFIC DEMETHYLASE AND HISTIDYL-HYDROXYLASE NO66, 60S RIBOSOMAL PROTEIN L8, MANGANESE (II) ION, ... (7 entities in total)
Functional Keywordsoxidoreductase, non-heme, iron-binding, dsbh, 2- oxoglutarate, dioxygenase, jmjc domain, ribosome biogenesis, nuclear protein, rpl8, beta-hydroxylation, transcription and epigenetic regulation, signaling
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains4
Total molecular weight114567.02
Authors
Chowdhury, R.,Schofield, C.J. (deposition date: 2013-10-23, release date: 2014-05-14, Last modification date: 2019-02-06)
Primary citation
Chowdhury, R.,Sekirnik, R.,Brissett, N.C.,Krojer, T.,Ho, C.H.,Ng, S.S.,Clifton, I.J.,Ge, W.,Kershaw, N.J.,Fox, G.C.,Muniz, J.R.C.,Vollmar, M.,Phillips, C.,Pilka, E.S.,Kavanagh, K.L.,von Delft, F.,Oppermann, U.,McDonough, M.A.,Doherty, A.J.,Schofield, C.J.
Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 510:422-426, 2014
PubMed: 24814345 (PDB entries with the same primary citation)
DOI: 10.1038/nature13263
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.23 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.24712 0.1% 2.8% 3.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4ccn
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Molmil generated image of 4ccn
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Molmil generated image of 4ccn
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More Biological unit images

Molmil generated image of 4ccn
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Molmil generated image of 4ccn
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Molmil generated image of 4ccn
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (4ccn.pdb1.gz [318.83 KB])
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