6YW3

HIF PROLYL HYDROXYLASE 2 (PHD2/ EGLN1) in complex with N-Oxalyl Glycine (NOG), HIF-1ALPHA CODD (556-574) and a RaPID-derived cyclic peptide 3C (14-mer)

Summary for 6YW3

• Entry DOI: 10.2210/pdb6yw3/pdb
• Related: 5L9B 5L9R 5L9V 6YW1 6YW2
• Descriptor: Egl nine homolog 1, PHD2-SPECIFIC RaPID CYCLIC PEPTIDE 3C (14-MER), Hypoxia-inducible factor 1-alpha, ... (8 entities in total)
• Functional Keywords: oxidoreductase, non-heme dioxygenase, iron, 2-oxoglutarate, hypoxia-inducible factor, hif, hif prolyl hydroxylase domain 2, phd2, egln1, oxygenase, hypoxia, dna-binding, metal-binding, transcription, helix-loop-helix-beta, dsbh, facial triad, cytoplasm, transcription/epigenetic regulation, signaling, development, cell structure, beta-hydroxylation, transcription activator/inhibitor, ubl conjugation, polymorphism, vitamin c, zinc-finger, familial erythrocytosis, breast cancer, transcription complex
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 30482.34

Authors

Chowdhury, R.,Schofield, C.J. (deposition date: 2020-04-29, release date: 2020-12-30, Last modification date: 2024-01-24)

• Primary citation: Chowdhury, R.,Abboud, M.I.,McAllister, T.E.,Banerji, B.,Bhushan, B.,Sorensen, J.L.,Kawamura, A.,Schofield, C.J.; Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2.; Sci Rep, 10:21964-21964, 2020; PubMed: 33319810; DOI: 10.1038/s41598-020-76307-8

Experimental method

X-RAY DIFFRACTION (2.279 Å)