Author results

1LTX
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STRUCTURE OF RAB ESCORT PROTEIN-1 IN COMPLEX WITH RAB GERANYLGERANYL TRANSFERASE AND ISOPRENOID
Descriptor:RAB GERANYLGERANYLTRANSFERASE ALPHA SUBUNIT, RAB GERANYLGERANYLTRANSFERASE BETA SUBUNIT, Rab Escort Protein 1, ...
Authors:Pylypenko, O., Rak, A., Reents, R., Niculae, A., Thoma, N.H., Waldmann, H., Schlichting, I., Goody, R.S., Alexandrov, K.
Deposit date:2002-05-21
Release date:2003-05-21
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of Rab Escort Protein-1 in Complex with Rab Geranylgeranyltransferase
Mol.Cell, 11, 2003
1VG0
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THE CRYSTAL STRUCTURES OF THE REP-1 PROTEIN IN COMPLEX WITH MONOPRENYLATED RAB7 PROTEIN
Descriptor:Rab proteins geranylgeranyltransferase component A 1, Ras-related protein Rab-7, CHLORIDE ION, ...
Authors:Rak, A., Pylypenko, O., Niculae, A., Pyatkov, K., Goody, R.S., Alexandrov, K.
Deposit date:2004-04-22
Release date:2004-07-20
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease
Cell(Cambridge,Mass.), 117, 2004
1VG1
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GDP-BOUND RAB7
Descriptor:Ras-related protein Rab-7, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE
Authors:Rak, A., Pylypenko, O., Niculae, A., Pyatkov, K., Goody, R.S., Alexandrov, K.
Deposit date:2004-04-22
Release date:2004-07-20
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease
Cell(Cambridge,Mass.), 117, 2004
1VG8
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GPPNHP-BOUND RAB7
Descriptor:Ras-related protein Rab-7, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Rak, A., Pylypenko, O., Niculae, A., Pyatkov, K., Goody, R.S., Alexandrov, K.
Deposit date:2004-04-23
Release date:2004-07-20
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease
Cell(Cambridge,Mass.), 117, 2004
1VG9
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THE CRYSTAL STRUCTURES OF THE REP-1 PROTEIN IN COMPLEX WITH C-TERMINALLY TRUNCATED RAB7 PROTEIN
Descriptor:Rab proteins geranylgeranyltransferase component A 1, Ras-related protein Rab-7, MAGNESIUM ION, ...
Authors:Rak, A., Pylypenko, O., Niculae, A., Pyatkov, K., Goody, R.S., Alexandrov, K.
Deposit date:2004-04-23
Release date:2004-07-20
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease
Cell(Cambridge,Mass.), 117, 2004
1FKM
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CRYSTAL STRUCTURE OF THE YPT/RAB-GAP DOMAIN OF GYP1P
Descriptor:PROTEIN (GYP1P)
Authors:Rak, A., Fedorov, R., Alexandrov, K., Albert, S., Goody, R.S., Gallwitz, D., Scheidig, A.J.
Deposit date:2000-08-09
Release date:2001-02-09
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the GAP domain of Gyp1p: first insights into interaction with Ypt/Rab proteins.
EMBO J., 19, 2000
1UKV
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STRUCTURE OF RABGDP-DISSOCIATION INHIBITOR IN COMPLEX WITH PRENYLATED YPT1 GTPASE
Descriptor:Secretory pathway GDP dissociation inhibitor, GTP-binding protein YPT1, MAGNESIUM ION, ...
Authors:Rak, A., Pylypenko, O., Durek, T., Watzke, A., Kushnir, S., Brunsveld, L., Waldmann, H., Goody, R.S., Alexandrov, K.
Deposit date:2003-09-01
Release date:2004-09-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of Rab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase
Science, 302, 2003
2BCG
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STRUCTURE OF DOUBLY PRENYLATED YPT1:GDI COMPLEX
Descriptor:Secretory pathway GDP dissociation inhibitor, GTP-binding protein YPT1, GERAN-8-YL GERAN, ...
Authors:Pylypenko, O., Rak, A., Alexandrov, K.
Deposit date:2005-10-19
Release date:2006-01-17
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Structure of doubly prenylated Ypt1:GDI complex and the mechanism of GDI-mediated Rab recycling
Embo J., 25, 2006
3C72
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ENGINEERED RABGGTASE IN COMPLEX WITH A PEPTIDOMIMETIC INHIBITOR
Descriptor:Geranylgeranyl transferase type-2 subunit alpha, Geranylgeranyl transferase type-2 subunit beta, ZINC ION, ...
Authors:Guo, Z., Wu, Y.W., Tan, K.T., Bon, R.S., Guiu-Rozas, E., Delon, C., Nguyen, U.T., Wetzel, S., Arndt, S., Goody, R.S., Blankenfeldt, W., Alexandrov, K., Waldmann, H.
Deposit date:2008-02-06
Release date:2008-07-22
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Development of selective RabGGTase inhibitors and crystal structure of a RabGGTase-inhibitor complex.
Angew.Chem.Int.Ed.Engl., 47, 2008
3DSS
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CRYSTAL STRUCTURE OF RABGGTASE(DELTA LRR; DELTA IG)
Descriptor:Geranylgeranyl transferase type-2 subunit alpha, Geranylgeranyl transferase type-2 subunit beta, ZINC ION, ...
Authors:Guo, Z., Yu, S., Goody, R.S., Alexandrov, K., Blankenfeldt, W.
Deposit date:2008-07-14
Release date:2008-09-09
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation
Embo J., 27, 2008
3DST
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CRYSTAL STRUCTURE OF RABGGTASE(DELTA LRR; DELTA IG)IN COMPLEX WITH GERANYLGERANYL PYROPHOSPHATE
Descriptor:Geranylgeranyl transferase type-2 subunit alpha, Geranylgeranyl transferase type-2 subunit beta, GERANYLGERANYL DIPHOSPHATE, ...
Authors:Guo, Z., Yu, S., Goody, R.S., Alexandrov, K., Blankenfeldt, W.
Deposit date:2008-07-14
Release date:2008-09-09
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation
Embo J., 27, 2008
3DSU
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CRYSTAL STRUCTURE OF RABGGTASE(DELTA LRR; DELTA IG)IN COMPLEX WITH FARNESYL PYROPHOSPHATE
Descriptor:Geranylgeranyl transferase type-2 subunit alpha, Geranylgeranyl transferase type-2 subunit beta, FARNESYL DIPHOSPHATE, ...
Authors:Guo, Z., Yu, S., Goody, R.S., Alexandrov, K., Blankenfeldt, W.
Deposit date:2008-07-14
Release date:2008-09-09
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation
Embo J., 27, 2008
3DSV
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CRYSTAL STRUCTURE OF RABGGTASE(DELTA LRR; DELTA IG)IN COMPLEX WITH MONO-PRENYLATED PEPTIDE SER-CYS-SER-CYS(GG) DERIVATED FROM RAB7
Descriptor:Geranylgeranyl transferase type-2 subunit alpha, Geranylgeranyl transferase type-2 subunit beta, ZINC ION, ...
Authors:Guo, Z., Yu, S., Goody, R.S., Alexandrov, K., Blankenfeldt, W.
Deposit date:2008-07-14
Release date:2008-09-09
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation
Embo J., 27, 2008
3DSW
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CRYSTAL STRUCTURE OF RABGGTASE(DELTA LRR; DELTA IG)IN COMPLEX WITH MONO-PRENYLATED PEPTIDE SER-CYS(GG)-SER-CYS DERIVATED FROM RAB7
Descriptor:Geranylgeranyl transferase type-2 subunit alpha, Geranylgeranyl transferase type-2 subunit beta, ZINC ION, ...
Authors:Guo, Z., Yu, S., Goody, R.S., Alexandrov, K., Blankenfeldt, W.
Deposit date:2008-07-14
Release date:2008-09-09
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation
Embo J., 27, 2008
3DSX
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CRYSTAL STRUCTURE OF RABGGTASE(DELTA LRR; DELTA IG)IN COMPLEX WITH DI-PRENYLATED PEPTIDE SER-CYS(GG)-SER-CYS(GG) DERIVATED FROM RAB7
Descriptor:Geranylgeranyl transferase type-2 subunit alpha, Geranylgeranyl transferase type-2 subunit beta, ZINC ION, ...
Authors:Guo, Z., Yu, S., Goody, R.S., Alexandrov, K., Blankenfeldt, W.
Deposit date:2008-07-14
Release date:2008-09-09
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation
Embo J., 27, 2008
3EU5
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CRYSTAL STRUCTURE OF FTASE(ALPHA-SUBUNIT; BETA-SUBUNIT DELTA C10) IN COMPLEX WITH BIOTINGPP
Descriptor:Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha, Protein farnesyltransferase subunit beta, ZINC ION, ...
Authors:Guo, Z., Nguyen, U.T.T., Delon, C., Bon, R.S., Blankenfeldt, W., Goody, R.S., Waldmann, H., Wolters, D., Alexandrov, K.
Deposit date:2008-10-09
Release date:2009-07-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Analysis of the eukaryotic prenylome by isoprenoid affinity tagging
Nat.Chem.Biol., 5, 2009
3EUV
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CRYSTAL STRUCTURE OF FTASE(ALPHA-SUBUNIT; BETA-SUBUNIT DELTA C10, W102T, Y154T) IN COMPLEX WITH BIOTINGPP
Descriptor:Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha, Protein farnesyltransferase subunit beta, ZINC ION, ...
Authors:Guo, Z., Nguyen, U.T.T., Delon, C., Bon, R.S., Blankenfeldt, W., Goody, R.S., Waldmann, H., Wolters, D., Alexandrov, K.
Deposit date:2008-10-11
Release date:2009-07-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Analysis of the eukaryotic prenylome by isoprenoid affinity tagging
Nat.Chem.Biol., 5, 2009
3HXB
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ENGINEERED RABGGTASE IN COMPLEX WITH A PEPTIDOMIMETIC INHIBITOR (COMPOUND 6)
Descriptor:Geranylgeranyl transferase type-2 subunit alpha, Geranylgeranyl transferase type-2 subunit beta, N-[(benzyloxy)carbonyl]-D-tyrosyl-L-phenylalanyl-L-tyrosine, ...
Authors:Guo, Z., Alexandrov, K., Waldmann, H., Goody, R.S., Blankenfeldt, W.
Deposit date:2009-06-20
Release date:2009-09-08
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Design, synthesis, and characterization of Peptide-based rab geranylgeranyl transferase inhibitors
J.Med.Chem., 52, 2009
3HXC
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ENGINEERED RABGGTASE IN COMPLEX WITH A PEPTIDOMIMETIC INHIBITOR (COMPOUND 8)
Descriptor:Geranylgeranyl transferase type-2 subunit alpha, Geranylgeranyl transferase type-2 subunit beta, ZINC ION, ...
Authors:Guo, Z., Alexandrov, K., Waldmann, H., Goody, R.S., Blankenfeldt, W.
Deposit date:2009-06-20
Release date:2009-09-08
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Design, synthesis, and characterization of Peptide-based rab geranylgeranyl transferase inhibitors
J.Med.Chem., 52, 2009
3HXD
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ENGINEERED RABGGTASE IN COMPLEX WITH A PEPTIDOMIMETIC INHIBITOR (COMPOUND 9)
Descriptor:Geranylgeranyl transferase type-2 subunit alpha, Geranylgeranyl transferase type-2 subunit beta, ZINC ION, ...
Authors:Guo, Z., Alexandrov, K., Waldmann, H., Goody, R.S., Blankenfeldt, W.
Deposit date:2009-06-20
Release date:2009-09-08
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Design, synthesis, and characterization of Peptide-based rab geranylgeranyl transferase inhibitors
J.Med.Chem., 52, 2009
3HXE
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ENGINEERED RABGGTASE IN COMPLEX WITH A PEPTIDOMIMETIC INHIBITOR (COMPOUND 37)
Descriptor:Geranylgeranyl transferase type-2 subunit alpha, Geranylgeranyl transferase type-2 subunit beta, ZINC ION, ...
Authors:Guo, Z., Alexandrov, K., Waldmann, H., Goody, R.S., Blankenfeldt, W.
Deposit date:2009-06-20
Release date:2009-09-08
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Design, synthesis, and characterization of Peptide-based rab geranylgeranyl transferase inhibitors
J.Med.Chem., 52, 2009
3HXF
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ENGINEERED RABGGTASE IN COMPLEX WITH A PEPTIDOMIMETIC INHIBITOR (COMPOUND 32)
Descriptor:Geranylgeranyl transferase type-2 subunit alpha, Geranylgeranyl transferase type-2 subunit beta, ZINC ION, ...
Authors:Guo, Z., Alexandrov, K., Waldmann, H., Goody, R.S., Blankenfeldt, W.
Deposit date:2009-06-20
Release date:2009-09-08
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Design, synthesis, and characterization of Peptide-based rab geranylgeranyl transferase inhibitors
J.Med.Chem., 52, 2009
3OGO
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STRUCTURE OF THE GFP:GFP-NANOBODY COMPLEX AT 2.8 A RESOLUTION IN SPACEGROUP P21212
Descriptor:Green fluorescent protein, GFP-nanobody, ISOPROPYL ALCOHOL
Authors:Kubala, M.H., Kovtun, O., Alexandrov, K., Collins, B.M.
Deposit date:2010-08-17
Release date:2010-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural and thermodynamic analysis of the GFP:GFP-nanobody complex.
Protein Sci., 19, 2010
3PZ1
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CRYSTAL STRUCTURE OF RABGGTASE(DELTA LRR; DELTA IG) IN COMPLEX WITH BMS3
Descriptor:Geranylgeranyl transferase type-2 subunit alpha, Geranylgeranyl transferase type-2 subunit beta, (3R)-3-benzyl-4-[(4-methoxyphenyl)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-carbonitrile, ...
Authors:Guo, Z., Bon, R.S., Stigter, E.A., Waldmann, H., Alexandrov, K., Blankenfeldt, W., Goody, R.S.
Deposit date:2010-12-14
Release date:2011-05-11
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure-Guided Development of Selective RabGGTase Inhibitors.
Angew.Chem.Int.Ed.Engl., 50, 2011
3PZ2
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CRYSTAL STRUCTURE OF RABGGTASE(DELTA LRR; DELTA IG) IN COMPLEX WITH BMS3 AND LIPID SUBSTRATE GGPP
Descriptor:Geranylgeranyl transferase type-2 subunit alpha, Geranylgeranyl transferase type-2 subunit beta, ZINC ION, ...
Authors:Guo, Z., Bon, R.S., Stigter, E.A., Waldmann, H., Alexandrov, K., Blankenfeldt, W., Goody, R.S.
Deposit date:2010-12-14
Release date:2011-05-11
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structure-Guided Development of Selective RabGGTase Inhibitors.
Angew.Chem.Int.Ed.Engl., 50, 2011
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