3PZ4
Crystal structure of FTase(ALPHA-subunit; BETA-subunit DELTA C10) in complex with BMS3 and lipid substrate FPP
Summary for 3PZ4
Entry DOI | 10.2210/pdb3pz4/pdb |
Related | 3PZ1 3PZ2 3PZ3 |
Descriptor | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha, Protein farnesyltransferase subunit beta, ZINC ION, ... (6 entities in total) |
Functional Keywords | protein prenylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Rattus norvegicus (rat) More |
Total number of polymer chains | 2 |
Total formula weight | 92886.86 |
Authors | Guo, Z.,Bon, R.S.,Stigter, E.A.,Waldmann, H.,Alexandrov, K.,Blankenfeldt, W.,Goody, R.S. (deposition date: 2010-12-14, release date: 2011-05-11, Last modification date: 2023-09-13) |
Primary citation | Bon, R.S.,Guo, Z.,Stigter, E.A.,Wetzel, S.,Menninger, S.,Wolf, A.,Choidas, A.,Alexandrov, K.,Blankenfeldt, W.,Goody, R.S.,Waldmann, H. Structure-Guided Development of Selective RabGGTase Inhibitors. Angew.Chem.Int.Ed.Engl., 50:4957-4961, 2011 Cited by PubMed: 21520375DOI: 10.1002/anie.201101210 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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