3HXE

Engineered RabGGTase in complex with a peptidomimetic inhibitor (compound 37)

Summary for 3HXE

Entry DOI	10.2210/pdb3hxe/pdb
Related	3HXB 3HXC 3HXD 3HXF
Descriptor	Geranylgeranyl transferase type-2 subunit alpha, Geranylgeranyl transferase type-2 subunit beta, ZINC ION, ... (6 entities in total)
Functional Keywords	protein prenylation inhibition, transferase
Biological source	Rattus norvegicus (rat) More
Total number of polymer chains	2
Total formula weight	76191.20
Authors	Guo, Z.,Alexandrov, K.,Waldmann, H.,Goody, R.S.,Blankenfeldt, W. (deposition date: 2009-06-20, release date: 2009-09-08, Last modification date: 2024-02-21)
Primary citation	Tan, K.T.,Guiu-Rozas, E.,Bon, R.S.,Guo, Z.,Delon, C.,Wetzel, S.,Arndt, S.,Alexandrov, K.,Waldmann, H.,Goody, R.S.,Wu, Y.W.,Blankenfeldt, W. Design, synthesis, and characterization of Peptide-based rab geranylgeranyl transferase inhibitors J.Med.Chem., 52:8025-8037, 2009 Cited by PubMed: 19894725 DOI: 10.1021/jm901117d PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation