3C72

Engineered RabGGTase in complex with a peptidomimetic inhibitor

Summary for 3C72

Entry DOI	10.2210/pdb3c72/pdb
Descriptor	Geranylgeranyl transferase type-2 subunit alpha, Geranylgeranyl transferase type-2 subunit beta, ZINC ION, ... (6 entities in total)
Functional Keywords	peptide inhibitor, rab prenylation, metal-binding, prenyltransferase, transferase, phosphoprotein
Biological source	Rattus norvegicus (rat) More
Total number of polymer chains	2
Total formula weight	76305.15
Authors	Guo, Z.,Wu, Y.W.,Tan, K.T.,Bon, R.S.,Guiu-Rozas, E.,Delon, C.,Nguyen, U.T.,Wetzel, S.,Arndt, S.,Goody, R.S.,Blankenfeldt, W.,Alexandrov, K.,Waldmann, H. (deposition date: 2008-02-06, release date: 2008-07-22, Last modification date: 2023-08-30)
Primary citation	Guo, Z.,Wu, Y.W.,Tan, K.T.,Bon, R.S.,Guiu-Rozas, E.,Delon, C.,Nguyen, T.U.,Wetzel, S.,Arndt, S.,Goody, R.S.,Blankenfeldt, W.,Alexandrov, K.,Waldmann, H. Development of selective RabGGTase inhibitors and crystal structure of a RabGGTase-inhibitor complex. Angew.Chem.Int.Ed.Engl., 47:3747-3750, 2008 Cited by PubMed: 18399557 DOI: 10.1002/anie.200705795 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation