3C72
Engineered RabGGTase in complex with a peptidomimetic inhibitor
Summary for 3C72
Entry DOI | 10.2210/pdb3c72/pdb |
Descriptor | Geranylgeranyl transferase type-2 subunit alpha, Geranylgeranyl transferase type-2 subunit beta, ZINC ION, ... (6 entities in total) |
Functional Keywords | peptide inhibitor, rab prenylation, metal-binding, prenyltransferase, transferase, phosphoprotein |
Biological source | Rattus norvegicus (rat) More |
Total number of polymer chains | 2 |
Total formula weight | 76305.15 |
Authors | Guo, Z.,Wu, Y.W.,Tan, K.T.,Bon, R.S.,Guiu-Rozas, E.,Delon, C.,Nguyen, U.T.,Wetzel, S.,Arndt, S.,Goody, R.S.,Blankenfeldt, W.,Alexandrov, K.,Waldmann, H. (deposition date: 2008-02-06, release date: 2008-07-22, Last modification date: 2023-08-30) |
Primary citation | Guo, Z.,Wu, Y.W.,Tan, K.T.,Bon, R.S.,Guiu-Rozas, E.,Delon, C.,Nguyen, T.U.,Wetzel, S.,Arndt, S.,Goody, R.S.,Blankenfeldt, W.,Alexandrov, K.,Waldmann, H. Development of selective RabGGTase inhibitors and crystal structure of a RabGGTase-inhibitor complex. Angew.Chem.Int.Ed.Engl., 47:3747-3750, 2008 Cited by PubMed: 18399557DOI: 10.1002/anie.200705795 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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