3C72

Engineered RabGGTase in complex with a peptidomimetic inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Geranylgeranyl transferase type-2 subunit alpha	polymer	334	38693.8	1	UniProt (Q08602) Pfam (PF01239) In PDB	Rattus norvegicus (rat)	Geranylgeranyl transferase type II subunit alpha, Rab geranylgeranyltransferase subunit alpha, Rab geranyl-geranyltransferase subunit alpha, Rab GG transferase alpha, Rab GGTase alpha
2	B	Geranylgeranyl transferase type-2 subunit beta	polymer	331	36892.2	1	UniProt (Q08603) Pfam (PF00432) In PDB	Rattus norvegicus (rat)	Geranylgeranyl transferase type II subunit beta, Rab geranylgeranyltransferase subunit beta, Rab geranyl-geranyltransferase subunit beta, Rab GG transferase beta, Rab GGTase beta
3	B	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
4	B	CALCIUM ION	non-polymer		40.1	1	Chemie (CA)
5	B	N-[(benzyloxy)carbonyl]-L-histidyl-N-methyl-L-phenylalanyl-L-tyrosine	non-polymer		613.7	1	Chemie (CX1)
6		water	water		18.0	191	Chemie (HOH)

Sequence modifications

A: 1 - 236 (UniProt: Q08602)

PDB	External Database	Details
Gly -3	-	expression tag
His -2	-	expression tag
Gly -1	-	expression tag
His 0	-	expression tag

A: 242 - 330 (UniProt: Q08602)

PDB	External Database	Details
Gly 237	-	linker
Ala 238	-	linker
Gly 239	-	linker
Ser 240	-	linker
Gly 241	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	75586.0
Non-Polymers*	Number of molecules	3
	Total formula weight	719.1
All*	Total formula weight	76305.2

*Water molecules are not included.