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3PZ3

Crystal structure of RabGGTase(DELTA LRR; DELTA IG) in Complex with BMS-analogue 14

Summary for 3PZ3
Entry DOI10.2210/pdb3pz3/pdb
Related3PZ1 3PZ2 3PZ4
DescriptorGeranylgeranyl transferase type-2 subunit alpha, Geranylgeranyl transferase type-2 subunit beta, ZINC ION, ... (6 entities in total)
Functional Keywordsprotein prenylation, fusion protein, chimera protein, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceRattus norvegicus (rat)
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Total number of polymer chains2
Total formula weight76110.95
Authors
Guo, Z.,Bon, R.S.,Stigter, E.A.,Waldmann, H.,Alexandrov, K.,Blankenfeldt, W.,Goody, R.S. (deposition date: 2010-12-14, release date: 2011-05-11, Last modification date: 2023-09-13)
Primary citationBon, R.S.,Guo, Z.,Stigter, E.A.,Wetzel, S.,Menninger, S.,Wolf, A.,Choidas, A.,Alexandrov, K.,Blankenfeldt, W.,Goody, R.S.,Waldmann, H.
Structure-Guided Development of Selective RabGGTase Inhibitors.
Angew.Chem.Int.Ed.Engl., 50:4957-4961, 2011
Cited by
PubMed: 21520375
DOI: 10.1002/anie.201101210
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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