3HXB
Engineered RabGGTase in complex with a peptidomimetic inhibitor (compound 6)
Summary for 3HXB
Entry DOI | 10.2210/pdb3hxb/pdb |
Related | 3HXC 3HXD 3HXE 3HXF |
Descriptor | Geranylgeranyl transferase type-2 subunit alpha, Geranylgeranyl transferase type-2 subunit beta, N-[(benzyloxy)carbonyl]-D-tyrosyl-L-phenylalanyl-L-tyrosine, ... (5 entities in total) |
Functional Keywords | protein prenylation inhibition, metal-binding, prenyltransferase, transferase, zinc |
Biological source | Rattus norvegicus (rat) More |
Total number of polymer chains | 2 |
Total formula weight | 76024.84 |
Authors | Guo, Z.,Alexandrov, K.,Waldmann, H.,Goody, R.S.,Blankenfeldt, W. (deposition date: 2009-06-20, release date: 2009-09-08, Last modification date: 2023-09-06) |
Primary citation | Tan, K.T.,Guiu-Rozas, E.,Bon, R.S.,Guo, Z.,Delon, C.,Wetzel, S.,Arndt, S.,Alexandrov, K.,Waldmann, H.,Goody, R.S.,Wu, Y.W.,Blankenfeldt, W. Design, synthesis, and characterization of Peptide-based rab geranylgeranyl transferase inhibitors J.Med.Chem., 52:8025-8037, 2009 Cited by PubMed: 19894725DOI: 10.1021/jm901117d PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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