3HXB

Engineered RabGGTase in complex with a peptidomimetic inhibitor (compound 6)

Summary for 3HXB

Entry DOI	10.2210/pdb3hxb/pdb
Related	3HXC 3HXD 3HXE 3HXF
Descriptor	Geranylgeranyl transferase type-2 subunit alpha, Geranylgeranyl transferase type-2 subunit beta, N-[(benzyloxy)carbonyl]-D-tyrosyl-L-phenylalanyl-L-tyrosine, ... (5 entities in total)
Functional Keywords	protein prenylation inhibition, metal-binding, prenyltransferase, transferase, zinc
Biological source	Rattus norvegicus (rat) More
Total number of polymer chains	2
Total formula weight	76024.84
Authors	Guo, Z.,Alexandrov, K.,Waldmann, H.,Goody, R.S.,Blankenfeldt, W. (deposition date: 2009-06-20, release date: 2009-09-08, Last modification date: 2023-09-06)
Primary citation	Tan, K.T.,Guiu-Rozas, E.,Bon, R.S.,Guo, Z.,Delon, C.,Wetzel, S.,Arndt, S.,Alexandrov, K.,Waldmann, H.,Goody, R.S.,Wu, Y.W.,Blankenfeldt, W. Design, synthesis, and characterization of Peptide-based rab geranylgeranyl transferase inhibitors J.Med.Chem., 52:8025-8037, 2009 Cited by PubMed: 19894725 DOI: 10.1021/jm901117d PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation