3HXD

Engineered RabGGTase in complex with a peptidomimetic inhibitor (compound 9)

Summary for 3HXD

• Entry DOI: 10.2210/pdb3hxd/pdb
• Related: 3HXB 3HXC 3HXE 3HXF
• Descriptor: Geranylgeranyl transferase type-2 subunit alpha, Geranylgeranyl transferase type-2 subunit beta, ZINC ION, ... (6 entities in total)
• Functional Keywords: protein prenylation inhibition, transferase
• Biological source: Rattus norvegicus (rat); More
• Total number of polymer chains: 2
• Total formula weight: 76067.92

Authors

Guo, Z.,Alexandrov, K.,Waldmann, H.,Goody, R.S.,Blankenfeldt, W. (deposition date: 2009-06-20, release date: 2009-09-08, Last modification date: 2024-02-21)

• Primary citation: Tan, K.T.,Guiu-Rozas, E.,Bon, R.S.,Guo, Z.,Delon, C.,Wetzel, S.,Arndt, S.,Alexandrov, K.,Waldmann, H.,Goody, R.S.,Wu, Y.W.,Blankenfeldt, W.; Design, synthesis, and characterization of Peptide-based rab geranylgeranyl transferase inhibitors; J.Med.Chem., 52:8025-8037, 2009; PubMed: 19894725; DOI: 10.1021/jm901117d

Experimental method

X-RAY DIFFRACTION (1.95 Å)