3PZ1

Crystal structure of RabGGTase(DELTA LRR; DELTA IG) in Complex with BMS3

Summary for 3PZ1

Entry DOI	10.2210/pdb3pz1/pdb
Related	3PZ2 3PZ3 3PZ4
Descriptor	Geranylgeranyl transferase type-2 subunit alpha, Geranylgeranyl transferase type-2 subunit beta, (3R)-3-benzyl-4-[(4-methoxyphenyl)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-carbonitrile, ... (7 entities in total)
Functional Keywords	protein prenylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Rattus norvegicus (rat) More
Total number of polymer chains	2
Total formula weight	76205.27
Authors	Guo, Z.,Bon, R.S.,Stigter, E.A.,Waldmann, H.,Alexandrov, K.,Blankenfeldt, W.,Goody, R.S. (deposition date: 2010-12-14, release date: 2011-05-11, Last modification date: 2023-09-13)
Primary citation	Bon, R.S.,Guo, Z.,Stigter, E.A.,Wetzel, S.,Menninger, S.,Wolf, A.,Choidas, A.,Alexandrov, K.,Blankenfeldt, W.,Goody, R.S.,Waldmann, H. Structure-Guided Development of Selective RabGGTase Inhibitors. Angew.Chem.Int.Ed.Engl., 50:4957-4961, 2011 Cited by PubMed: 21520375 DOI: 10.1002/anie.201101210 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation