4EHM
RabGGTase in complex with covalently bound Psoromic acid
Summary for 4EHM
Entry DOI | 10.2210/pdb4ehm/pdb |
Descriptor | Geranylgeranyl transferase type-2 subunit alpha, Geranylgeranyl transferase type-2 subunit beta, 4-formyl-3-hydroxy-8-methoxy-1,9-dimethyl-11-oxo-11H-dibenzo[b,e][1,4]dioxepine-6-carboxylic acid, ... (6 entities in total) |
Functional Keywords | prenylation, inhibition, psoromic acid, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Rattus norvegicus (Rat) More |
Total number of polymer chains | 2 |
Total formula weight | 75528.20 |
Authors | Guo, Z.,Deraeve, C.,Bon, R.S.,Alexandrov, K.,Waldmann, H.,Wu, Y.W.,Goody, R.S.,Blankenfeldt, W. (deposition date: 2012-04-02, release date: 2012-05-30, Last modification date: 2017-08-09) |
Primary citation | Deraeve, C.,Guo, Z.,Bon, R.S.,Blankenfeldt, W.,Dilucrezia, R.,Wolf, A.,Menninger, S.,Stigter, E.A.,Wetzel, S.,Choidas, A.,Alexandrov, K.,Waldmann, H.,Goody, R.S.,Wu, Y.W. Psoromic Acid is a Selective and Covalent Rab-Prenylation Inhibitor Targeting Autoinhibited RabGGTase J.Am.Chem.Soc., 134:7384-7391, 2012 Cited by PubMed: 22480322DOI: 10.1021/ja211305j PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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