7T1K
 
 | | Crystal structure of a superbinder Fes SH2 domain (sFes1) in complex with a high affinity phosphopeptide | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, MALONATE ION, ... | | 著者 | Martyn, G.D, Singer, A.U, Veggiani, G, Kurinov, I, Sicheri, F, Sidhu, S.S. | | 登録日 | 2021-12-02 | | 公開日 | 2022-08-24 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | | 主引用文献 | Engineered SH2 Domains for Targeted Phosphoproteomics.
Acs Chem.Biol., 17, 2022
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7T1L
 | | Crystal structure of a superbinder Fes SH2 domain (sFesS) in complex with a high affinity phosphopeptide | | 分子名称: | CHLORIDE ION, SODIUM ION, Synthetic phosphotyrosine-containing Ezrin-derived peptide, ... | | 著者 | Martyn, G.D, Singer, A.U, Veggiani, G, Kurinov, I, Sicheri, F, Sidhu, S.S. | | 登録日 | 2021-12-02 | | 公開日 | 2022-08-24 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Engineered SH2 Domains for Targeted Phosphoproteomics.
Acs Chem.Biol., 17, 2022
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7T1U
 | | Crystal structure of a superbinder Src SH2 domain (sSrcF) in complex with a high affinity phosphopeptide | | 分子名称: | Proto-oncogene tyrosine-protein kinase Src, Synthetic phosphopeptide, ZINC ION | | 著者 | Martyn, G.D, Singer, A.U, Manczyk, N, Veggiani, G, Kurinov, I, Sicheri, F, Sidhu, S.S. | | 登録日 | 2021-12-02 | | 公開日 | 2022-08-24 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Engineered SH2 Domains for Targeted Phosphoproteomics.
Acs Chem.Biol., 17, 2022
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4ROJ
 | | Crystal Structure of the VAV2 SH2 domain in complex with TXNIP phosphorylated peptide | | 分子名称: | Guanine nucleotide exchange factor VAV2, Thioredoxin-interacting protein, UNKNOWN ATOM OR ION | | 著者 | Liu, Y, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | 登録日 | 2014-10-28 | | 公開日 | 2014-12-10 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Crystal Structure of the VAV2 SH2 domain in complex with TXNIP phosphorylated peptide
TO BE PUBLISHED
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4TZI
 | | Structure of unliganded Lyn SH2 domain | | 分子名称: | Tyrosine-protein kinase Lyn | | 著者 | Wybenga-Groot, L.E. | | 登録日 | 2014-07-10 | | 公開日 | 2015-01-21 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Tyrosine Phosphorylation of the Lyn Src Homology 2 (SH2) Domain Modulates Its Binding Affinity and Specificity.
Mol.Cell Proteomics, 14, 2015
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4U1P
 | | Human Fyn-SH2 domain in complex with a synthetic high-affinity phospho-peptide | | 分子名称: | Middle T antigen, POLYETHYLENE GLYCOL (N=34), SODIUM ION, ... | | 著者 | Garcia-Pino, A, Huculeci, R, Lenaerts, T, van Nuland, N.A.J. | | 登録日 | 2014-07-16 | | 公開日 | 2015-07-29 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Human Fyn-SH2 domain in complex with a synthetic high-affinity phospho-peptide
To Be Published
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4U17
 | | Swapped dimer of the human Fyn-SH2 domain | | 分子名称: | 1,2-ETHANEDIOL, PHOSPHATE ION, Tyrosine-protein kinase Fyn | | 著者 | Garcia-Pino, A, Huculeci, R, Lenaerts, T, van Nuland, N.A.J. | | 登録日 | 2014-07-15 | | 公開日 | 2015-07-29 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | | 主引用文献 | Swapped dimer of the human Fyn-SH2 domain
To Be Published
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5X94
 | | Crystal structure of SHP2_SH2-CagA EPIYA_D peptide complex | | 分子名称: | Cag pathogenicity island protein, Tyrosine-protein phosphatase non-receptor type 11 | | 著者 | Senda, M, Senda, T. | | 登録日 | 2017-03-05 | | 公開日 | 2017-09-13 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Differential Mechanisms for SHP2 Binding and Activation Are Exploited by Geographically Distinct Helicobacter pylori CagA Oncoproteins.
Cell Rep, 20, 2017
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5AUL
 | | PI3K p85 C-terminal SH2 domain/CD28-derived peptide complex | | 分子名称: | GLYCEROL, Phosphatidylinositol 3-kinase regulatory subunit alpha, T-cell-specific surface glycoprotein CD28 | | 著者 | Inaba, S, Numoto, N, Morii, H, Ikura, T, Oda, M, Ito, N. | | 登録日 | 2015-04-28 | | 公開日 | 2016-05-25 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | Crystal Structures and Thermodynamic Analysis Reveal Distinct Mechanisms of CD28 Phosphopeptide Binding to the Src Homology 2 (SH2) Domains of Three Adaptor Proteins
J. Biol. Chem., 292, 2017
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4K44
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5CDW
 | | Crystal Structure Analysis of a mutant Grb2 SH2 domain (W121G) with a pYVNV peptide | | 分子名称: | Growth factor receptor-bound protein 2, SER-PTR-VAL-ASN-VAL-GLN | | 著者 | Papaioannou, D, Geibel, S, Kunze, M, Kay, C, Waksman, G. | | 登録日 | 2015-07-05 | | 公開日 | 2016-05-25 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.602 Å) | | 主引用文献 | Structural and biophysical investigation of the interaction of a mutant Grb2 SH2 domain (W121G) with its cognate phosphopeptide.
Protein Sci., 25, 2016
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4K45
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5D0J
 | | Grb7 SH2 with inhibitor peptide | | 分子名称: | G7-TEdFP peptide, Growth factor receptor-bound protein 7, PHOSPHATE ION | | 著者 | Gunzburg, M.J, Watson, G.M, Wilce, J.A, Wilce, M.C.J. | | 登録日 | 2015-08-03 | | 公開日 | 2016-06-15 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7.
Sci Rep, 6, 2016
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5DF6
 | | Crystal structure of PTPN11 tandem SH2 domains in complex with a TXNIP peptide | | 分子名称: | Tyrosine-protein phosphatase non-receptor type 11, UNKNOWN ATOM OR ION, txnip | | 著者 | Dong, A, Li, W, Tempel, W, Liu, Y, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | 登録日 | 2015-08-26 | | 公開日 | 2015-09-23 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | | 主引用文献 | Structural basis for the regulatory role of the PPxY motifs in the thioredoxin-interacting protein TXNIP.
Biochem.J., 473, 2016
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5EEQ
 | | Grb7 SH2 with the G7-B1 bicyclic peptide inhibitor | | 分子名称: | Bicyclic Peptide Inhibitor, Growth factor receptor-bound protein 7, PHOSPHATE ION | | 著者 | Ambaye, N.D, Watson, G.M, Wilce, M.C.J, Wilce, G.M. | | 登録日 | 2015-10-23 | | 公開日 | 2016-06-15 | | 最終更新日 | 2024-04-17 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7.
Sci Rep, 6, 2016
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5EEL
 | | Grb7 SH2 with bicyclic peptide inhibitor | | 分子名称: | Bicyclic Peptide Inhibitor, FORMIC ACID, Growth factor receptor-bound protein 7, ... | | 著者 | Watson, G.M, Gunzburg, M.J, Wilce, M.C.J, Wilce, J.A. | | 登録日 | 2015-10-23 | | 公開日 | 2016-06-15 | | 最終更新日 | 2018-12-26 | | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | | 主引用文献 | Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7.
Sci Rep, 6, 2016
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3PSJ
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3PQZ
 | | Grb7 SH2 with peptide | | 分子名称: | Growth factor receptor-bound protein 7, cyclic peptide | | 著者 | Wilce, J.A. | | 登録日 | 2010-11-29 | | 公開日 | 2011-07-20 | | 最終更新日 | 2011-09-21 | | 実験手法 | X-RAY DIFFRACTION (2.413 Å) | | 主引用文献 | Structural basis of binding by cyclic nonphosphorylated Peptide antagonists of grb7 implicated in breast cancer progression
J.Mol.Biol., 412, 2011
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3PSK
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4EIH
 | | Crystal structure of Arg SH2 domain | | 分子名称: | Abelson tyrosine-protein kinase 2, CHLORIDE ION | | 著者 | Liu, W, MacGrath, S.M, Koleske, A.J, Boggon, T.J. | | 登録日 | 2012-04-05 | | 公開日 | 2013-04-10 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Two Amino Acid Residues Confer Different Binding Affinities of Abelson Family Kinase Src Homology 2 Domains for Phosphorylated Cortactin.
J.Biol.Chem., 289, 2014
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4EY0
 | | Structure of tandem SH2 domains from PLCgamma1 | | 分子名称: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | | 著者 | Cole, A.R, Mas-Droux, C.P, Bunney, T.D, Katan, M. | | 登録日 | 2012-05-01 | | 公開日 | 2012-10-31 | | 最終更新日 | 2013-06-19 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structural and Functional Integration of the PLCgamma Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation.
Structure, 20, 2012
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4F59
 | | Triple mutant Src SH2 domain | | 分子名称: | Proto-oncogene tyrosine-protein kinase Src | | 著者 | Kaneko, T, Huang, H, Cao, X, Li, C, Voss, C, Sidhu, S.S, Li, S.S. | | 登録日 | 2012-05-12 | | 公開日 | 2012-10-03 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | | 主引用文献 | Superbinder SH2 Domains Act as Antagonists of Cell Signaling.
Sci.Signal., 5, 2012
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4F5A
 | | Triple mutant Src SH2 domain bound to phosphate ion | | 分子名称: | PHOSPHATE ION, Proto-oncogene tyrosine-protein kinase Src | | 著者 | Kaneko, T, Huang, H, Cao, X, Li, C, Voss, C, Sidhu, S.S, Li, S.S. | | 登録日 | 2012-05-12 | | 公開日 | 2012-10-03 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Superbinder SH2 Domains Act as Antagonists of Cell Signaling.
Sci.Signal., 5, 2012
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4F5B
 | | Triple mutant Src SH2 domain bound to phosphotyrosine | | 分子名称: | O-PHOSPHOTYROSINE, Proto-oncogene tyrosine-protein kinase Src | | 著者 | Kaneko, T, Huang, H, Cao, X, Li, C, Voss, C, Sidhu, S.S, Li, S.S. | | 登録日 | 2012-05-12 | | 公開日 | 2012-10-03 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | | 主引用文献 | Superbinder SH2 Domains Act as Antagonists of Cell Signaling.
Sci.Signal., 5, 2012
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3S8N
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