5CDW

Crystal Structure Analysis of a mutant Grb2 SH2 domain (W121G) with a pYVNV peptide

Summary for 5CDW

• Entry DOI: 10.2210/pdb5cdw/pdb
• Descriptor: Growth factor receptor-bound protein 2, SER-PTR-VAL-ASN-VAL-GLN (3 entities in total)
• Functional Keywords: sh2 domain, phosphotyrosine, ligand, w121g mutation, signaling protein
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus : P62993
• Total number of polymer chains: 32
• Total formula weight: 197821.62

Authors

Papaioannou, D.,Geibel, S.,Kunze, M.,Kay, C.,Waksman, G. (deposition date: 2015-07-05, release date: 2016-05-25, Last modification date: 2024-01-10)

• Primary citation: Papaioannou, D.,Geibel, S.,Kunze, M.B.,Kay, C.W.,Waksman, G.; Structural and biophysical investigation of the interaction of a mutant Grb2 SH2 domain (W121G) with its cognate phosphopeptide.; Protein Sci., 25:627-637, 2016; PubMed: 26645482; DOI: 10.1002/pro.2856

Experimental method

X-RAY DIFFRACTION (2.602 Å)