4F5B

Triple mutant Src SH2 domain bound to phosphotyrosine

Summary for 4F5B

Entry DOI	10.2210/pdb4f5b/pdb
Related	4F59 4F5A
Descriptor	Proto-oncogene tyrosine-protein kinase Src, O-PHOSPHOTYROSINE (3 entities in total)
Functional Keywords	sh2 domain, cell signalling, phosphotyrosine, protein binding
Biological source	Homo sapiens (human)
Cellular location	Cell membrane: P12931
Total number of polymer chains	1
Total formula weight	12960.48
Authors	Kaneko, T.,Huang, H.,Cao, X.,Li, C.,Voss, C.,Sidhu, S.S.,Li, S.S. (deposition date: 2012-05-12, release date: 2012-10-03, Last modification date: 2024-03-13)
Primary citation	Kaneko, T.,Huang, H.,Cao, X.,Li, X.,Li, C.,Voss, C.,Sidhu, S.S.,Li, S.S. Superbinder SH2 Domains Act as Antagonists of Cell Signaling. Sci.Signal., 5:ra68-ra68, 2012 Cited by PubMed: 23012655 DOI: 10.1126/scisignal.2003021 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.57 Å)

Structure validation