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PDB: 373 results

4V6V
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Tetracycline resistance protein Tet(O) bound to the ribosome
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Li, W, Atkinson, G.C, Thakor, N.S, Allas, U, Lu, C, Chan, K.Y, Tenson, T, Schulten, K, Wilson, K.S, Hauryliuk, V, Frank, J.
Deposit date:2013-02-25
Release date:2014-07-09
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (9.8 Å)
Cite:Mechanism of tetracycline resistance by ribosomal protection protein Tet(O).
Nat Commun, 4, 2013
6XA1
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BU of 6xa1 by Molmil
Structure of a drug-like compound stalled human translation termination complex
Descriptor: 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ...
Authors:Li, W, Cate, J.
Deposit date:2020-06-03
Release date:2020-10-07
Last modified:2020-10-14
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Selective inhibition of human translation termination by a drug-like compound.
Nat Commun, 11, 2020
1LCY
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BU of 1lcy by Molmil
Crystal Structure of the Mitochondrial Serine Protease HtrA2
Descriptor: HtrA2 serine protease
Authors:Li, W, Srinivasula, S.M, Chai, J, Li, P, Wu, J.W, Zhang, Z, Alnemri, E.S, Shi, Y.
Deposit date:2002-04-07
Release date:2002-05-22
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi.
Nat.Struct.Biol., 9, 2002
4ZM9
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BU of 4zm9 by Molmil
Crystal structure of circularly permuted human asparaginase-like protein 1
Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, BETA-MERCAPTOETHANOL, CITRATE ANION, ...
Authors:Li, W.Z, Zhang, Y.
Deposit date:2015-05-02
Release date:2016-02-17
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Intramolecular Cleavage of the hASRGL1 Homodimer Occurs in Two Stages.
Biochemistry, 55, 2016
6OLF
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Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AA and PE tRNAs
Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ...
Authors:Li, W, Cate, J.H.D.
Deposit date:2019-04-16
Release date:2019-06-19
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
Nat.Struct.Mol.Biol., 26, 2019
6OLZ
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BU of 6olz by Molmil
Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with PP tRNA
Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ...
Authors:Li, W, Cate, J.H.D.
Deposit date:2019-04-17
Release date:2019-06-19
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
Nat.Struct.Mol.Biol., 26, 2019
6OLG
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BU of 6olg by Molmil
Human ribosome nascent chain complex stalled by a drug-like small molecule (CDH1_RNC with PP tRNA)
Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ...
Authors:Li, W, Cate, J.H.D.
Deposit date:2019-04-16
Release date:2019-06-19
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
Nat.Struct.Mol.Biol., 26, 2019
6OLI
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BU of 6oli by Molmil
Structure of human ribosome nascent chain complex selectively stalled by a drug-like small molecule (USO1-RNC)
Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ...
Authors:Li, W, Cate, J.H.D.
Deposit date:2019-04-16
Release date:2019-06-19
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
Nat.Struct.Mol.Biol., 26, 2019
8IGB
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BU of 8igb by Molmil
Crystal structure of SARS-Cov-2 main protease P132H mutant in complex with GC376
Descriptor: 3C-like proteinase nsp5, N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide
Authors:Li, W.W, Zhang, J, Li, J.
Deposit date:2023-02-20
Release date:2024-03-06
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Structural Basis for Coronaviral Main Proteases Inhibition by the 3CLpro Inhibitor GC376
J.Mol.Biol., 436, 2024
6OM0
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BU of 6om0 by Molmil
Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with AP and PE tRNAs
Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ...
Authors:Li, W, Cate, J.H.D.
Deposit date:2019-04-17
Release date:2019-06-19
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
Nat.Struct.Mol.Biol., 26, 2019
6OLE
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BU of 6ole by Molmil
Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AP and PE tRNAs
Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ...
Authors:Li, W, Cate, J.H.D.
Deposit date:2019-04-16
Release date:2019-06-19
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
Nat.Struct.Mol.Biol., 26, 2019
6OM7
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BU of 6om7 by Molmil
Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like small molecule with AA and PE tRNAs
Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ...
Authors:Li, W, Cate, J.H.D.
Deposit date:2019-04-18
Release date:2019-06-19
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
Nat.Struct.Mol.Biol., 26, 2019
8HVN
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BU of 8hvn by Molmil
Crystal structure of SARS-Cov-2 main protease P132H mutant in complex with PF07321332
Descriptor: (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5
Authors:Li, W.W, Zhang, J, Li, J.
Deposit date:2022-12-27
Release date:2023-12-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of SARS-Cov-2 main protease P132H mutant in complex with PF07321332
To Be Published
8HUX
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BU of 8hux by Molmil
Crystal structure of SARS-Cov-2 main protease P132H mutant in complex with S217622
Descriptor: 3C-like proteinase nsp5, 6-[(6-chloranyl-2-methyl-indazol-5-yl)amino]-3-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-[[2,4,5-tris(fluoranyl)phenyl]methyl]-1,3,5-triazine-2,4-dione
Authors:Li, W.W, Zhang, J, Li, J.
Deposit date:2022-12-24
Release date:2023-06-21
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Structural basis for the inhibition of coronaviral main proteases by ensitrelvir.
Structure, 31, 2023
8HQI
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BU of 8hqi by Molmil
Crystal structure of SARS-Cov-2 main protease P132H mutant in complex with inhibitor YH-53
Descriptor: 3C-like proteinase nsp5, N-[(2S)-1-[[(2S)-1-(1,3-benzothiazol-2-yl)-1-oxidanylidene-3-[(3S)-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]-4-methoxy-1H-indole-2-carboxamide
Authors:Li, W.W, Zhang, J, Li, J.
Deposit date:2022-12-13
Release date:2023-12-20
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structure of SARS-Cov-2 main protease P132H mutant in complex with inhibitor YH-53
To Be Published
1ZR4
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BU of 1zr4 by Molmil
Structure of a Synaptic gamma-delta Resolvase Tetramer Covalently linked to two Cleaved DNAs
Descriptor: AAA, TCAGTGTCCGATAATTTAT, TTATCGGACACTG, ...
Authors:Li, W, Kamtekar, S, Xiong, Y, Sarkis, G.J, Grindley, N.D, Steitz, T.A.
Deposit date:2005-05-19
Release date:2005-08-30
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structure of a synaptic gamma delta resolvase tetramer covalently linked to two cleaved DNAs.
Science, 309, 2005
4D3Z
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BU of 4d3z by Molmil
The structure of inactive prolegumain from chinese hamster, trigonal space group.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, PROLEGUMAIN
Authors:Li, W, Heinz, D.W, Krausze, J.
Deposit date:2014-10-24
Release date:2016-01-20
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A Detailed Look Into Chinese Hamster Legumain Active Site Structure and Exploration of its Function
To be Published
4D3X
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BU of 4d3x by Molmil
The structure of mature legumain from chinese hamster.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, LEGUMAIN
Authors:Li, W, Heinz, D.W, Krausze, J.
Deposit date:2014-10-24
Release date:2016-01-20
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.848 Å)
Cite:A Detailed Look Into Chinese Hamster Legumain Active Site Structure and Exploration of its Function
To be Published
4D3Y
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BU of 4d3y by Molmil
The structure of inactive prolegumain from chinese hamster.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, LEGUMAIN
Authors:Li, W, Heinz, D.W, Krausze, J.
Deposit date:2014-10-24
Release date:2016-01-20
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A Detailed Look Into Chinese Hamster Legumain Active Site Structure and Exploration of its Function
To be Published
3UDC
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BU of 3udc by Molmil
Crystal structure of a membrane protein
Descriptor: Small-conductance mechanosensitive channel, C-terminal peptide from Small-conductance mechanosensitive channel
Authors:Li, W, Ge, J, Yang, M.
Deposit date:2011-10-28
Release date:2012-10-31
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.355 Å)
Cite:Structure and molecular mechanism of an anion-selective mechanosensitive channel of small conductance
Proc.Natl.Acad.Sci.USA, 109, 2012
2YXR
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BU of 2yxr by Molmil
The plug domain of the SecY protein stablizes the closed state of the translocation channel and maintains a membrane seal
Descriptor: Preprotein translocase secG subunit, Preprotein translocase subunit secE, Preprotein translocase subunit secY
Authors:Li, W, Schulman, S.
Deposit date:2007-04-27
Release date:2007-08-14
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:The plug domain of the SecY protein stabilizes the closed state of the translocation channel and maintains a membrane seal
Mol.Cell, 26, 2007
2YXQ
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BU of 2yxq by Molmil
The plug domain of the SecY protein stablizes the closed state of the translocation channel and maintains a membrane seal
Descriptor: Preprotein translocase secG subunit, Preprotein translocase subunit secE, Preprotein translocase subunit secY
Authors:Li, W, Schulman, S.
Deposit date:2007-04-27
Release date:2007-08-14
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:The plug domain of the SecY protein stabilizes the closed state of the translocation channel and maintains a membrane seal
Mol.Cell, 26, 2007
1H3L
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BU of 1h3l by Molmil
N-terminal fragment of SigR from Streptomyces coelicolor
Descriptor: RNA POLYMERASE SIGMA FACTOR
Authors:Li, W, Stevenson, C.E.M, Burton, N, Jakimowicz, P, Paget, M.S.B, Buttner, M.J, Lawson, D.M, Kleanthous, C.
Deposit date:2002-09-10
Release date:2002-10-03
Last modified:2015-09-23
Method:X-RAY DIFFRACTION (2.375 Å)
Cite:Identification and Structure of the Anti-Sigma Factor-Binding Domain of the Disulfide-Stress Regulated Sigma Factor Sigma(R) from Streptomyces Coelicolor
J.Mol.Biol., 323, 2002
4LGI
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BU of 4lgi by Molmil
N-terminal truncated NleC structure
Descriptor: Uncharacterized protein
Authors:Li, W.Q, Liu, Y.X, Sheng, X.L, Yan, C.Y, Wang, J.W.
Deposit date:2013-06-28
Release date:2014-01-15
Last modified:2015-02-25
Method:X-RAY DIFFRACTION (2.301 Å)
Cite:Structure and mechanism of a type III secretion protease, NleC
Acta Crystallogr.,Sect.D, 70, 2014
4LGJ
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BU of 4lgj by Molmil
Crystal structure and mechanism of a type III secretion protease
Descriptor: Uncharacterized protein, ZINC ION
Authors:Li, W.Q, Liu, Y.X, Sheng, X.L, Yan, C.Y, Wang, J.W.
Deposit date:2013-06-28
Release date:2014-01-15
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structure and mechanism of a type III secretion protease, NleC
Acta Crystallogr.,Sect.D, 70, 2014

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