5X94
Crystal structure of SHP2_SH2-CagA EPIYA_D peptide complex
Summary for 5X94
Entry DOI | 10.2210/pdb5x94/pdb |
Related | 5X7B |
Descriptor | Tyrosine-protein phosphatase non-receptor type 11, Cag pathogenicity island protein (3 entities in total) |
Functional Keywords | helicobacter pylori caga, sh2 domain-containing protein tyrosine phosphatase 2 (shp2), caga polymorphism, hydrolase |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm : Q06124 |
Total number of polymer chains | 6 |
Total formula weight | 56087.02 |
Authors | |
Primary citation | Hayashi, T.,Senda, M.,Suzuki, N.,Nishikawa, H.,Ben, C.,Tang, C.,Nagase, L.,Inoue, K.,Senda, T.,Hatakeyama, M. Differential Mechanisms for SHP2 Binding and Activation Are Exploited by Geographically Distinct Helicobacter pylori CagA Oncoproteins. Cell Rep, 20:2876-2890, 2017 Cited by PubMed: 28930683DOI: 10.1016/j.celrep.2017.08.080 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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