7T1L

Crystal structure of a superbinder Fes SH2 domain (sFesS) in complex with a high affinity phosphopeptide

Summary for 7T1L

Entry DOI	10.2210/pdb7t1l/pdb
Descriptor	Tyrosine-protein kinase Fes/Fps, Synthetic phosphotyrosine-containing Ezrin-derived peptide, SODIUM ION, ... (5 entities in total)
Functional Keywords	src homology 2 (sh2), superbinder, rational engineering, signaling protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	24221.96
Authors	Martyn, G.D.,Singer, A.U.,Veggiani, G.,Kurinov, I.,Sicheri, F.,Sidhu, S.S. (deposition date: 2021-12-02, release date: 2022-08-24, Last modification date: 2023-11-15)
Primary citation	Martyn, G.D.,Veggiani, G.,Kusebauch, U.,Morrone, S.R.,Yates, B.P.,Singer, A.U.,Tong, J.,Manczyk, N.,Gish, G.,Sun, Z.,Kurinov, I.,Sicheri, F.,Moran, M.F.,Moritz, R.L.,Sidhu, S.S. Engineered SH2 Domains for Targeted Phosphoproteomics. Acs Chem.Biol., 17:1472-1484, 2022 Cited by PubMed: 35613471 DOI: 10.1021/acschembio.2c00051 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.35 Å)

Structure validation