5EEL
Grb7 SH2 with bicyclic peptide inhibitor
Summary for 5EEL
Entry DOI | 10.2210/pdb5eel/pdb |
Related | 5EEQ |
Descriptor | Growth factor receptor-bound protein 7, Bicyclic Peptide Inhibitor, MALONIC ACID, ... (6 entities in total) |
Functional Keywords | sh2, inhibitor, bicyclic, signaling protein-peptide complex, signaling protein/peptide |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 12 |
Total formula weight | 89883.70 |
Authors | Watson, G.M.,Gunzburg, M.J.,Wilce, M.C.J.,Wilce, J.A. (deposition date: 2015-10-23, release date: 2016-06-15, Last modification date: 2018-12-26) |
Primary citation | Gunzburg, M.J.,Kulkarni, K.,Watson, G.M.,Ambaye, N.D.,Del Borgo, M.P.,Brandt, R.,Pero, S.C.,Perlmutter, P.,Wilce, M.C.,Wilce, J.A. Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7. Sci Rep, 6:27060-27060, 2016 Cited by PubMed: 27257138DOI: 10.1038/srep27060 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.47 Å) |
Structure validation
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