PDB: 2199 resultsInfo pagesStatus searchChemie searchBIRD

---

7BL8	BAZ2A bromodomain in complex with the chemical probe BAZ2-ICR Descriptor: 4-[5-(1-methylpyrazol-4-yl)-3-[2-(1-methylpyrazol-4-yl)ethyl]imidazol-4-yl]benzenecarbonitrile, Bromodomain adjacent to zinc finger domain protein 2A Authors: Dalle Vedove, A, Cazzanelli, G, Caflisch, A, Lolli, G. Deposit date: 2021-01-18 Release date: 2022-03-02 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Chemical probes in the BAZ2A bromodomain to be published
7BLA	BAZ2A bromodomain in complex with TP-238 chemical probe Descriptor: 6-{4-[3-(dimethylamino)propoxy]phenyl}-2-(methylsulfonyl)-N-[3-(1H-pyrazol-1-yl)propyl]pyrimidin-4-amine, Bromodomain adjacent to zinc finger domain protein 2A Authors: Dalle Vedove, A, Cazzanelli, G, Caflisch, A, Lolli, G. Deposit date: 2021-01-18 Release date: 2022-03-02 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.086 Å) Cite: Chemical probes in the BAZ2A bromodomain to be published
7BLB	BAZ2A bromodomain in complex with GSK4027 chemical probe Descriptor: 4-bromo-2-methyl-5-[[(3~{R},5~{R})-1-methyl-5-phenyl-piperidin-3-yl]amino]pyridazin-3-one, Bromodomain adjacent to zinc finger domain protein 2A Authors: Dalle Vedove, A, Cazzanelli, G, Caflisch, A, Lolli, G. Deposit date: 2021-01-18 Release date: 2022-03-02 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Chemical probes in the BAZ2A bromodomain to be published
7C4I	High resolution structure of BRPF1 Bromo Domain from Biortus Descriptor: GLYCEROL, POTASSIUM ION, Peregrin Authors: Wang, F, Lin, D, Lv, Z, Zhu, B. Deposit date: 2020-05-18 Release date: 2020-07-08 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.37 Å) Cite: High resolution structure of BRPF1 Bromo Domain from Biortus To Be Published
7C6P	Bromodomain-containing 4 BD2 in complex with 3',4',7,8- Tetrahydroxyflavonoid Descriptor: 2-[3,4-bis(oxidanyl)phenyl]-7,8-bis(oxidanyl)chromen-4-one, Bromodomain-containing protein 4 Authors: Li, J, Yu, K, Luo, Y, Zheng, W, Liang, W, Zhu, J. Deposit date: 2020-05-22 Release date: 2021-05-12 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.73 Å) Cite: Discovery of the natural product 3',4',7,8-tetrahydroxyflavone as a novel and potent selective BRD4 bromodomain 2 inhibitor. J Enzyme Inhib Med Chem, 36, 2021
7C2Z	Bromodomain-containing 4 BD1 in complex with 3',4',7,8-Tetrahydroxyflavone Descriptor: 2-[3,4-bis(oxidanyl)phenyl]-7,8-bis(oxidanyl)chromen-4-one, Bromodomain-containing protein 4, FORMIC ACID Authors: Li, J, Zhu, J. Deposit date: 2020-05-10 Release date: 2021-05-12 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Discovery of the natural product 3',4',7,8-tetrahydroxyflavone as a novel and potent selective BRD4 bromodomain 2 inhibitor. J Enzyme Inhib Med Chem, 36, 2021
8FTA	Crystal Structure of the second bromodomain of human Polybromo-1 (PB1) in complex with compound 16 Descriptor: (2S)-5-chloro-2-(3-methylphenyl)-2,3-dihydroquinazolin-4(1H)-one, Protein polybromo-1, ZINC ION Authors: Nunez, R, Smith, B.C. Deposit date: 2023-01-11 Release date: 2024-01-24 Method: X-RAY DIFFRACTION (1.78 Å) Cite: Crystal Structure of the second bromodomain of human Polybromo-1 (PB1) in complex with compound 16 To Be Published
8FUP	Bromodomain of CBP liganded with BMS-536924 and CCS-1477 Descriptor: (3M)-4-{[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-3-[4-methyl-6-(morpholin-4-yl)-1H-benzimidazol-2-yl]pyridin-2(1H)-one, (6S)-1-[3,4-bis(fluoranyl)phenyl]-6-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-(4-methoxycyclohexyl)benzimidazol-2-yl]piperidin-2-one, 1,2-ETHANEDIOL, ... Authors: Schonbrunn, E, Bikowitz, M. Deposit date: 2023-01-18 Release date: 2024-02-07 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structural basis of CBP and EP300 interaction with kinase inhibitors To Be Published
8FVS	Bromodomain of CBP liganded with CCS1477int Descriptor: 1,2-ETHANEDIOL, Histone acetyltransferase, MAGNESIUM ION, ... Authors: Schonbrunn, E, Bikowitz, M. Deposit date: 2023-01-19 Release date: 2024-01-24 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Group 3 medulloblastoma transcriptional networks collapse under domain specific EP300/CBP inhibition. Nat Commun, 15, 2024
8FVK	First bromodomain of BRD4 liganded with CCS-1477 Descriptor: (6S)-1-[3,4-bis(fluoranyl)phenyl]-6-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-(4-methoxycyclohexyl)benzimidazol-2-yl]piperidin-2-one, 1,2-ETHANEDIOL, Bromodomain-containing protein 4 Authors: Schonbrunn, E, Bikowitz, M. Deposit date: 2023-01-19 Release date: 2024-02-07 Method: X-RAY DIFFRACTION (1.53 Å) Cite: Group 3 medulloblastoma transcriptional networks are sensitive to EP300/CBP bromodomain inhibition To Be Published
8FVF	Bromodomain of EP300 liganded with CCS-1477 Descriptor: (6S)-1-[3,4-bis(fluoranyl)phenyl]-6-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-(4-methoxycyclohexyl)benzimidazol-2-yl]piperidin-2-one, 1,2-ETHANEDIOL, Histone acetyltransferase p300, ... Authors: Schonbrunn, E, Bikowitz, M. Deposit date: 2023-01-18 Release date: 2024-02-07 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Group 3 medulloblastoma transcriptional networks are sensitive to EP300/CBP bromodomain inhibition To Be Published
8FXA	Bromodomain of CBP liganded with iCBP4 Descriptor: (6S)-1-[3,5-bis(trifluoromethyl)phenyl]-6-{(5M)-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(1s,4R)-4-methoxycyclohexyl]-1H-benzimidazol-2-yl}piperidin-2-one, 1,2-ETHANEDIOL, CREB-binding protein Authors: Schonbrunn, E, Bikowitz, M. Deposit date: 2023-01-24 Release date: 2024-02-07 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Group 3 medulloblastoma transcriptional networks are sensitive to EP300/CBP bromodomain inhibition To Be Published
8FXE	Bromodomain of CBP liganded with iCBP6 Descriptor: (6S)-1-(3-tert-butylphenyl)-6-{(5P)-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(1s,4R)-4-methoxycyclohexyl]-1H-benzimidazol-2-yl}piperidin-2-one, 1,2-ETHANEDIOL, CREB-binding protein Authors: Schonbrunn, E, Bikowitz, M. Deposit date: 2023-01-24 Release date: 2024-02-07 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Group 3 medulloblastoma transcriptional networks are sensitive to EP300/CBP bromodomain inhibition To be published
8FV2	Bromodomain of CBP liganded with CCS-1477 Descriptor: (6S)-1-[3,4-bis(fluoranyl)phenyl]-6-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-(4-methoxycyclohexyl)benzimidazol-2-yl]piperidin-2-one, 1,2-ETHANEDIOL, CREB-binding protein, ... Authors: Schonbrunn, E, Bikowitz, M. Deposit date: 2023-01-18 Release date: 2024-02-07 Method: X-RAY DIFFRACTION (1.87 Å) Cite: Group 3 medulloblastoma transcriptional networks are sensitive to EP300/CBP bromodomain inhibition To Be Published
8FXO	Bromodomain of CBP liganded with iCBP8 Descriptor: (6S)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)-6-{(5M)-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(1s,4R)-4-methoxycyclohexyl]-1H-benzimidazol-2-yl}piperidin-2-one, CREB-binding protein Authors: Schonbrunn, E, Bikowitz, M. Deposit date: 2023-01-25 Release date: 2024-02-07 Method: X-RAY DIFFRACTION (1.74 Å) Cite: Group 3 medulloblastoma transcriptional networks are sensitive to EP300/CBP bromodomain inhibition To be published
8FXN	Bromodomain of CBP liganded with iCBP7 Descriptor: 1,2-ETHANEDIOL, CREB-binding protein, tert-butyl {(1R,4s)-4-[(5M)-2-[(2S)-1-(3-tert-butylphenyl)-6-oxopiperidin-2-yl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1H-benzimidazol-1-yl]cyclohexyl}carbamate Authors: Schonbrunn, E, Bikowitz, M. Deposit date: 2023-01-25 Release date: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: Group 3 medulloblastoma transcriptional networks are sensitive to EP300/CBP bromodomain inhibition To be published
8G6T	Bromodomain of CBP liganded with inhibitor iCBP2 Descriptor: (6S)-1-(3,4-dibromophenyl)-6-{(5M)-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(1s,4R)-4-methoxycyclohexyl]-1H-benzimidazol-2-yl}piperidin-2-one, CREB-binding protein, NICKEL (II) ION Authors: Schonbrunn, E, Bikowitz, M. Deposit date: 2023-02-15 Release date: 2024-02-21 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Group 3 medulloblastoma transcriptional networks are sensitive to EP300/CBP bromodomain inhibition To be published
8GA2	Bromodomain of CBP liganded with inhibitor iCBP5 Descriptor: (6S)-6-{(5M)-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(1s,4R)-4-methoxycyclohexyl]-1H-benzimidazol-2-yl}-1-phenylpiperidin-2-one, 1,2-ETHANEDIOL, CREB-binding protein Authors: Schonbrunn, E, Bikowitz, M. Deposit date: 2023-02-22 Release date: 2024-02-28 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Group 3 medulloblastoma transcriptional networks collapse under domain specific EP300/CBP inhibition. Nat Commun, 15, 2024
8GQ0	Crystal structure of BRD4 bromodomain 1 (BD1) in complex with STL233497 Descriptor: Bromodomain-containing protein 4, FORMIC ACID, GLYCEROL, ... Authors: Park, T.H, Lee, B.I. Deposit date: 2022-08-27 Release date: 2023-01-18 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.44 Å) Cite: Crystal structure of [1,2,4]triazolo[4,3-b]pyridazine derivatives as BRD4 bromodomain inhibitors and structure-activity relationship study. Sci Rep, 13, 2023
8GPZ	Crystal structure of BRD4 bromodomain 1 (BD1) in complex with C239-0012 Descriptor: 3-methyl-6-(4-methylpiperidin-1-yl)-[1,2,4]triazolo[4,3-b]pyridazine, Bromodomain-containing protein 4, FORMIC ACID, ... Authors: Park, T.H, Lee, B.I. Deposit date: 2022-08-27 Release date: 2023-01-18 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.528 Å) Cite: Crystal structure of [1,2,4]triazolo[4,3-b]pyridazine derivatives as BRD4 bromodomain inhibitors and structure-activity relationship study. Sci Rep, 13, 2023
8IBQ	Bromodomain and Extra-terminal Domain (BET) BRD4 Descriptor: 7-[2-fluoranyl-3-(1,3,5-trimethylpyrazol-4-yl)phenyl]-1~{H}-imidazo[4,5-b]pyridine, Bromodomain-containing protein 4 Authors: Cao, D, Zhiyan, D, Xiong, B. Deposit date: 2023-02-10 Release date: 2023-10-04 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Discovery of 1 H -Imidazo[4,5- b ]pyridine Derivatives as Potent and Selective BET Inhibitors for the Management of Neuropathic Pain. J.Med.Chem., 66, 2023
8IDH	Bromodomain and Extra-terminal Domain (BET) BRD4 Descriptor: 7-[2-fluoranyl-3-(1,3,5-trimethylpyrazol-4-yl)phenyl]-1~{H}-imidazo[4,5-b]pyridine, Bromodomain-containing protein 4 Authors: Cao, D, Zhiyan, D, Xiong, B. Deposit date: 2023-02-13 Release date: 2023-10-04 Method: X-RAY DIFFRACTION (1.57 Å) Cite: Discovery of 1 H -Imidazo[4,5- b ]pyridine Derivatives as Potent and Selective BET Inhibitors for the Management of Neuropathic Pain. J.Med.Chem., 66, 2023
8K14	X-ray crystal structure of 18a in BRD4(1) Descriptor: 4-[8-methoxy-2-methyl-1-(1-phenylethyl)imidazo[4,5-c]quinolin-7-yl]-3,5-dimethyl-1,2-oxazole, Bromodomain-containing protein 4 Authors: Xu, H, Shen, H, Zhang, Y, Xu, Y, Li, R. Deposit date: 2023-07-10 Release date: 2024-03-27 Method: X-RAY DIFFRACTION (1.28 Å) Cite: Discovery of (R)-4-(8-methoxy-2-methyl-1-(1-phenylethy)-1H-imidazo[4,5-c]quinnolin-7-yl)-3,5-dimethylisoxazole as a potent and selective BET inhibitor for treatment of acute myeloid leukemia (AML) guided by FEP calculation. Eur.J.Med.Chem., 263, 2024
8P9G	Crystal structure of the first bromodomain of human BRD4 in complex with the dual BET/HDAC inhibitor NB390 Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, ~{N}-(2-aminophenyl)-4-[(~{E})-(6-methyl-7-oxidanyl-1~{H}-indol-4-yl)diazenyl]benzamide Authors: Balourdas, D.I, Bauer, N, Knapp, S, Joerger, A.C, Structural Genomics Consortium (SGC) Deposit date: 2023-06-06 Release date: 2023-07-05 Method: X-RAY DIFFRACTION (1.1 Å) Cite: Crystal structure of the first bromodomain of human BRD4 in complex with the dual BET/HDAC inhibitor NB390 to be published
8P9L	Crystal structure of the first bromodomain of human BRD4 in complex with the dual BET/HDAC inhibitor NB512 Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, ~{N}-(2-azanyl-5-phenyl-phenyl)-5-(6-methyl-7-oxidanylidene-1~{H}-pyrrolo[2,3-c]pyridin-4-yl)pyridine-2-carboxamide Authors: Balourdas, D.I, Bauer, N, Knapp, S, Joerger, A.C, Structural Genomics Consortium (SGC) Deposit date: 2023-06-06 Release date: 2023-07-05 Method: X-RAY DIFFRACTION (1.29 Å) Cite: Crystal structure of the first bromodomain of human BRD4 in complex with the dual BET/HDAC inhibitor NB512 to be published

<567891011121314151617181920>