8IBQ

Bromodomain and Extra-terminal Domain (BET) BRD4

Summary for 8IBQ

• Entry DOI: 10.2210/pdb8ibq/pdb
• Descriptor: Bromodomain-containing protein 4, 7-[2-fluoranyl-3-(1,3,5-trimethylpyrazol-4-yl)phenyl]-1~{H}-imidazo[4,5-b]pyridine (3 entities in total)
• Functional Keywords: binds acetylated lysine residues, dna binding protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 14974.32

Authors

Cao, D.,Zhiyan, D.,Xiong, B. (deposition date: 2023-02-10, release date: 2023-10-04)

• Primary citation: Chen, X.,Cao, D.,Liu, C.,Meng, F.,Zhang, Z.,Xu, R.,Tong, Y.,Xin, Y.,Zhang, W.,Kang, W.,Bao, Q.,Shen, J.,Xiong, B.,You, Q.,Jiang, Z.; Discovery of 1 H -Imidazo[4,5- b ]pyridine Derivatives as Potent and Selective BET Inhibitors for the Management of Neuropathic Pain.; J.Med.Chem., 66:8725-8744, 2023; PubMed: 37382379; DOI: 10.1021/acs.jmedchem.3c00372

Experimental method

X-RAY DIFFRACTION (1.45 Å)