8FXO

Bromodomain of CBP liganded with iCBP8

Summary for 8FXO

• Entry DOI: 10.2210/pdb8fxo/pdb
• Descriptor: CREB-binding protein, (6S)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)-6-{(5M)-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(1s,4R)-4-methoxycyclohexyl]-1H-benzimidazol-2-yl}piperidin-2-one (3 entities in total)
• Functional Keywords: bromodomain, small molecule ligand, complex, transcription, transcription-inhibitor complex, transcription/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 14404.53

Authors

Schonbrunn, E.,Bikowitz, M. (deposition date: 2023-01-25, release date: 2024-02-07)

• Primary citation: Schonbrunn, E.,Bikowitz, M.; Group 3 medulloblastoma transcriptional networks are sensitive to EP300/CBP bromodomain inhibition; To be published,

Experimental method

X-RAY DIFFRACTION (1.74 Å)