8FUP

Bromodomain of CBP liganded with BMS-536924 and CCS-1477

Summary for 8FUP

• Entry DOI: 10.2210/pdb8fup/pdb
• Related: 7UG5 7UGE 7UGF 7UGI 7UGL
• Descriptor: CREB-binding protein, (3M)-4-{[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-3-[4-methyl-6-(morpholin-4-yl)-1H-benzimidazol-2-yl]pyridin-2(1H)-one, (6S)-1-[3,4-bis(fluoranyl)phenyl]-6-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-(4-methoxycyclohexyl)benzimidazol-2-yl]piperidin-2-one, ... (5 entities in total)
• Functional Keywords: bromodomain, small molecule ligand, complex, transcription-inhibitor complex, transcription/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 29493.19

Authors

Schonbrunn, E.,Bikowitz, M. (deposition date: 2023-01-18, release date: 2024-02-07)

• Primary citation: Schonbrunn, E.,Bikowitz, M.; Structural basis of CBP and EP300 interaction with kinase inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.7 Å)