8G6T

Bromodomain of CBP liganded with inhibitor iCBP2

Summary for 8G6T

• Entry DOI: 10.2210/pdb8g6t/pdb
• Descriptor: CREB-binding protein, (6S)-1-(3,4-dibromophenyl)-6-{(5M)-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(1s,4R)-4-methoxycyclohexyl]-1H-benzimidazol-2-yl}piperidin-2-one, NICKEL (II) ION, ... (4 entities in total)
• Functional Keywords: bromodomain, complex, transcription, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 58134.55

Authors

Schonbrunn, E.,Bikowitz, M. (deposition date: 2023-02-15, release date: 2024-02-21)

• Primary citation: Schonbrunn, E.,Bikowitz, M.; Group 3 medulloblastoma transcriptional networks are sensitive to EP300/CBP bromodomain inhibition; To be published,

Experimental method

X-RAY DIFFRACTION (1.75 Å)