8FXA

Bromodomain of CBP liganded with iCBP4

Summary for 8FXA

• Entry DOI: 10.2210/pdb8fxa/pdb
• Descriptor: CREB-binding protein, 1,2-ETHANEDIOL, (6S)-1-[3,5-bis(trifluoromethyl)phenyl]-6-{(5M)-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(1s,4R)-4-methoxycyclohexyl]-1H-benzimidazol-2-yl}piperidin-2-one, ... (4 entities in total)
• Functional Keywords: bromodomain, small molecule ligand, complex, transcription, transcription-inhibitor complex, transcription/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 29213.26

Authors

Schonbrunn, E.,Bikowitz, M. (deposition date: 2023-01-24, release date: 2024-02-07)

• Primary citation: Schonbrunn, E.,Bikowitz, M.; Group 3 medulloblastoma transcriptional networks are sensitive to EP300/CBP bromodomain inhibition; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.65 Å)