7C2Z

Bromodomain-containing 4 BD1 in complex with 3',4',7,8-Tetrahydroxyflavone

Summary for 7C2Z

• Entry DOI: 10.2210/pdb7c2z/pdb
• Descriptor: Bromodomain-containing protein 4, 2-[3,4-bis(oxidanyl)phenyl]-7,8-bis(oxidanyl)chromen-4-one, FORMIC ACID, ... (4 entities in total)
• Functional Keywords: brd4, bd1, 3', 4', 7, 8- tetrahydroxyflavonoid, acute myeloid leukemia, c-myc, gene regulation
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 15344.56

Authors

Li, J.,Zhu, J. (deposition date: 2020-05-10, release date: 2021-05-12, Last modification date: 2023-11-29)

• Primary citation: Li, J.,Zou, W.,Yu, K.,Liu, B.,Liang, W.,Wang, L.,Lu, Y.,Jiang, Z.,Wang, A.,Zhu, J.; Discovery of the natural product 3',4',7,8-tetrahydroxyflavone as a novel and potent selective BRD4 bromodomain 2 inhibitor.; J Enzyme Inhib Med Chem, 36:903-913, 2021; PubMed: 33820450; DOI: 10.1080/14756366.2021.1906663

Experimental method

X-RAY DIFFRACTION (1.3 Å)