8FTA

Crystal Structure of the second bromodomain of human Polybromo-1 (PB1) in complex with compound 16

Summary for 8FTA

Entry DOI	10.2210/pdb8fta/pdb
Descriptor	Protein polybromo-1, (2S)-5-chloro-2-(3-methylphenyl)-2,3-dihydroquinazolin-4(1H)-one, ZINC ION, ... (4 entities in total)
Functional Keywords	protein polybromo-1, transcription
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	13634.85
Authors	Nunez, R.,Smith, B.C. (deposition date: 2023-01-11, release date: 2024-01-24, Last modification date: 2025-10-08)
Primary citation	Nunez, R.,Bursch, K.L.,Makowski, S.J.,Xue, M.,Cozzolino, K.A.,Shishodia, S.,Keyes, R.F.,Zhu, N.,Smith, B.C. Polybromo-1 Bromodomain Inhibitor Selectivity Is Mediated by a Unique Ligand-Binding Pocket Acs Med.Chem.Lett., 2025 Cited by DOI: 10.1021/acsmedchemlett.5c00352 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.78 Å)

Structure validation