8FXN

Bromodomain of CBP liganded with iCBP7

Summary for 8FXN

• Entry DOI: 10.2210/pdb8fxn/pdb
• Descriptor: CREB-binding protein, tert-butyl {(1R,4s)-4-[(5M)-2-[(2S)-1-(3-tert-butylphenyl)-6-oxopiperidin-2-yl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1H-benzimidazol-1-yl]cyclohexyl}carbamate, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: bromodomain, small molecule ligand, complex, transcription, transcription-inhibitor complex, transcription/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 14611.84

Authors

Schonbrunn, E.,Bikowitz, M. (deposition date: 2023-01-25, release date: 2024-02-07)

• Primary citation: Schonbrunn, E.,Bikowitz, M.; Group 3 medulloblastoma transcriptional networks are sensitive to EP300/CBP bromodomain inhibition; To be published,

Experimental method

X-RAY DIFFRACTION (2 Å)