8FXE

Bromodomain of CBP liganded with iCBP6

Summary for 8FXE

Entry DOI	10.2210/pdb8fxe/pdb
Descriptor	CREB-binding protein, (6S)-1-(3-tert-butylphenyl)-6-{(5P)-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(1s,4R)-4-methoxycyclohexyl]-1H-benzimidazol-2-yl}piperidin-2-one, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	bromodomain, small molecule ligand, complex, transcription, transcription-inhibitor complex, transcription/inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	14902.21
Authors	Schonbrunn, E.,Bikowitz, M. (deposition date: 2023-01-24, release date: 2024-02-07, Last modification date: 2024-06-05)
Primary citation	Shendy, N.A.M.,Bikowitz, M.,Sigua, L.H.,Zhang, Y.,Mercier, A.,Khashana, Y.,Nance, S.,Liu, Q.,Delahunty, I.M.,Robinson, S.,Goel, V.,Rees, M.G.,Ronan, M.A.,Wang, T.,Kocak, M.,Roth, J.A.,Wang, Y.,Freeman, B.B.,Orr, B.A.,Abraham, B.J.,Roussel, M.F.,Schonbrunn, E.,Qi, J.,Durbin, A.D. Group 3 medulloblastoma transcriptional networks collapse under domain specific EP300/CBP inhibition. Nat Commun, 15:3483-3483, 2024 Cited by PubMed: 38664416 DOI: 10.1038/s41467-024-47102-0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.55 Å)

Structure validation