8FVF

Bromodomain of EP300 liganded with CCS-1477

Summary for 8FVF

• Entry DOI: 10.2210/pdb8fvf/pdb
• Descriptor: Histone acetyltransferase p300, (6S)-1-[3,4-bis(fluoranyl)phenyl]-6-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-(4-methoxycyclohexyl)benzimidazol-2-yl]piperidin-2-one, 1,2-ETHANEDIOL, ... (6 entities in total)
• Functional Keywords: bromodomain, small molecule ligand, complex, transcription, transcription-inhibitor complex, transcription/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 29096.74

Authors

Schonbrunn, E.,Bikowitz, M. (deposition date: 2023-01-18, release date: 2024-02-07, Last modification date: 2024-06-05)

• Primary citation: Shendy, N.A.M.,Bikowitz, M.,Sigua, L.H.,Zhang, Y.,Mercier, A.,Khashana, Y.,Nance, S.,Liu, Q.,Delahunty, I.M.,Robinson, S.,Goel, V.,Rees, M.G.,Ronan, M.A.,Wang, T.,Kocak, M.,Roth, J.A.,Wang, Y.,Freeman, B.B.,Orr, B.A.,Abraham, B.J.,Roussel, M.F.,Schonbrunn, E.,Qi, J.,Durbin, A.D.; Group 3 medulloblastoma transcriptional networks collapse under domain specific EP300/CBP inhibition.; Nat Commun, 15:3483-3483, 2024; PubMed: 38664416; DOI: 10.1038/s41467-024-47102-0

Experimental method

X-RAY DIFFRACTION (2.1 Å)