8FVF

Bromodomain of EP300 liganded with CCS-1477

Summary for 8FVF

• Entry DOI: 10.2210/pdb8fvf/pdb
• Descriptor: Histone acetyltransferase p300, (6S)-1-[3,4-bis(fluoranyl)phenyl]-6-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-(4-methoxycyclohexyl)benzimidazol-2-yl]piperidin-2-one, 1,2-ETHANEDIOL, ... (6 entities in total)
• Functional Keywords: bromodomain, small molecule ligand, complex, transcription, transcription-inhibitor complex, transcription/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 29096.74

Authors

Schonbrunn, E.,Bikowitz, M. (deposition date: 2023-01-18, release date: 2024-02-07)

• Primary citation: Schonbrunn, E.,Bikowitz, M.; Group 3 medulloblastoma transcriptional networks are sensitive to EP300/CBP bromodomain inhibition; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.1 Å)